Award Data

Abstract We propose to initiate preclinical development of a gene therapeutic targeted to Alzheimer's Disease. The World Health Organization's and Alzheimer's Disease International's report on Dementia (2012) recognizes that the global burden of AlzheimerDisease is forecast to worsen significantly with prevalence predicted to double every 20 years. Interventions that could prov ...

? DESCRIPTION (provided by applicant): NMR is probably the most powerful and widely used analytical technique for structure determination and function elucidation of molecules of all types, but it suffers from low sensitivity, particularly for insoluble biological macromolecules. Dynamic Nuclear Polarization (DNP) with Magic Angle Spinning (MAS) has recently demonstrated S/N gains exceeding t ...

An approach is proposed to identify, characterize and integrate high temperature materials into harsh environment diagnostic systems. Program partner URI will sputter candidate conductive oxides with continuously varying levels of doping. Test specimens will be fabricated and systematically assessed using combinatorial synthesis to determine which exhibit the most favorable characteristics e.g., ...

DESCRIPTION (provided by applicant): The objective of the proposed project is to advance the development of novel peptides targeting MARCKS (Myristoylated Alanine-Rich C Kinase Substrate) protein as platform drug molecules for the treatment of Acute Lung Injury (ALI) and its more severe form, Acute Respiratory Distress Syndrome (ARDS), thereby providing the first pharmacologic therapeutic for this ...

DESCRIPTION (provided by applicant): Edible vaccines have received much attention since, in theory, they represent a source of vaccine that would stimulate mucosal immune responses, be cost-effective to produce, be safe to administer, and be stable to ship throughout the world. Studies proposed in this collaborative STTR effort will develop an oral vaccine against a non-toxic form of Staphylococcu ...

In the past, visual database development was a labor-intensive process. As newly available satellite imagery became available, databases would have to be rebuilt to incorporate updates. More recently, Diamond Visionics has developed technology to address this need, allowing for source data, including satellite imagery, to be easily integrated into visual simulation databases at runtime without r ...

ABSTRACT: This project addresses the need for high-efficiency broad-spectrum PV cells. The proposed original PV design is based on quantum dots with built-in charge (Q-BIC), where the dot charging is realized by selective doping of dot medium. The preliminary data demonstrate that the charged dots placed in a single p-n-junction strongly enhance harvesting and conversion of sub-bandgap photons an ...

Beltran proposes to develop an advanced methodology for analytical prediction of the long-term durability (25 years) of composite materials to be used in design of military facilities. Phase I Project is to outline a methodology concept relevant to emerging carbon fiber epoxy composite materials utilized in wet lay-up form for strengthening building construction and other structural appliations an ...

DESCRIPTION (provided by applicant): The overall goal of this project is to develop a computer-aided system that can assist the radiologist in targeting small pulmonary nodules during CT-guided lung biopsy. The estimated 3D needle trajectory along with the range of potential needle trajectories given varying degrees of needle steering will be calculated and displayed to the radiologist. We believe ...

DESCRIPTION (provided by applicant): The overall goal of this project is to design, fabricate, and test a compact, low-cost, confocal reflectance microscope capable of producing images of skin with quality comparable to those of current commercial instruments. The new design uses a scanner concept in which the optical path is passed through two prisms, which are rotated about the beam axis, result ...