Award Data

DESCRIPTION provided by applicant Even as the cost and throughput of commercial sequencers has continued to improve over the last years there is still a need to further reduce sequencing costs to increase throughput and sequencing accuracy and to reduce the costs associated with sample preparation Single molecule methods such as the Pacific Biosciences or nanopore technologies have the pot ...

DESCRIPTION provided by applicant Novel caveolin modulators as therapeutics for uveitis Project Summary This research proposal seeks to develop a novel therapy for uveitis based upon modulation of inflammatory signaling via caveolae Uveitis drives of blindness affecting people of working age and producing significant disability in patients with chronic disease Caveolin modulators such ...

DESCRIPTION provided by applicant Our vision is to realize a smart vivarium whereby a network of implanted microinfusion pumps may be remotely controlled from a single computing station Automation of drug administration and on demand dose adjustment in freely moving animals offers greater throughput and improved outcomes compared to existing technologies Towards this end this proposal focus ...

DESCRIPTION provided by applicant Caldera aims to develop an inexpensive stable selective decorporation decorp agent for cesium Cs Cs is easily obtainable by terrorists and treatments for exposures are Project Bioshield priorities for use in radiation nuclear emergencies high priority for DHHS NIH NIAID DAIT and a critical need for the Strategic National Stockpile S ...

DESCRIPTION provided by applicant In this proposal we seek to develop a new method and instrument to reduce the complexity of protein mixtures derived from human fluids with an eye to discovery of very low abundance protein biomarkers The proposed method accomplishes two tasks it reduces the dynamic range of the protein mixture by three or more orders of magnitude and it concentrates proteins ...

DESCRIPTION provided by applicant This SBIR Phase I proposal is intended to demonstrate the feasibility of developing a novel and effective therapeutic agent for acute radiation injury The threat of nuclear terrorism remains high and there is a possibility of a nuclear power plant leak both of which can cause acute radiation injury at a large scale Currently there are no therapeutic agents ...

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

DESCRIPTION provided by applicant The primary objective of the current project is to develop and evaluate the efficacy of on line brain plasticity based computerized assessment tool and training program for the prevention and delay of the onset of Alzheimerandapos s disease AD This novel therapeutic strategy is designed to re connect and reinvigorate Default Network DN brain areas by in ...

DESCRIPTION provided by applicant The broad long term goal of this project is to develop an optically based radiation biodosimeter that rapidly minutes measures changes in serological microRNA miRNA biomarkers to predict acute radiation syndrome ARS MicroRNAs miRNAs are short base non coding RNA strands that control a host of biological processes through regulation of pr ...

DESCRIPTION provided by applicant Mosquito borne members of the Flavivirus family include four serotypes of dengue virus DENV and West Nile Virus WNV and are classified as re emerging pathogens due to the frequency and severity of recent epidemics There are an estimated million DENV infections reported each year resulting in nearly deaths More than billion people are at ...