Award Data

DESCRIPTION (provided by applicant): Newborn screening (NBS) is a national public health initiative directed at identifying genetic or metabolic disorders in newborns which, if left untreated, are associated with significant morbidity or mortality. The role and scope of NBS is rapidly expanding given technological advances. Concurrent with this expansion is a widening gap in educational, emotional ...

DESCRIPTION (provided by applicant): Bone is one of the most implanted materials in the body, second only to blood. The market for bone grafting and dental implants is currently over 4.8 billion and is expected to grow rapidly in the future. Autograft has traditionally been used, but limited supply, donor-site risks, and cost created a demand for bone graft substitutes. As an osteoinductive bone ...

DESCRIPTION (provided by applicant): Molecular modeling using internal coordinates, rather than more traditional Cartesian approaches, is gaining recognition because of its significant computational efficiency advantages. Molsoft's ICM (Internal Coordinate Mechanics) is among the very few molecular modeling programs built from the ground up using internal coordinates. ICM is probably the only such ...

DESCRIPTION (provided by applicant): The main goal of this project is a development of the high throughput data acquisition system based on single photon spectrometer which enables detection and highly accurate recognition of sets containing millions of stochastically encoded microparticles and the validation of this system using genome-wide copy number analysis as a model system. As an outcome of ...

DESCRIPTION (provided by applicant): The overall objective of this Phase I STTR project is the commercialization of a new ionization source for ambient mass spectrometry based on the flowing afterglow of an atmospheric pressure glow discharge (APGD). This technology promises to have significant impact in pharmaceutical, clinical and biomedical research and its potential for enabling in vivo mass s ...

DESCRIPTION (provided by applicant): Stroke is a big, growing and costly problem. There are 550,000 first time and recurrent stroke survivors each year in the United States, costing an estimated 57.9 billion dollars for 2006. About one third of stroke survivors return to driving, most with little or no formal assessment or training. Although strokes are associated with significant neurological imp ...

DESCRIPTION (provided by applicant): One of the major problems in the fight against cancer is the intrinsic or acquired resistance of tumors to current cancer treatments, particularly that associated with multidrug transporters (MDT; e.g. P-glycoprotein (P-gp) and the multidrug associated protein (MRP1)). The clinical failures of early P-gp inhibitors, which either caused non-specific toxicity or ...

DESCRIPTION (provided by applicant): Recent cancer therapies have focused on using biologics to target specific signal transduction pathways implicated in the tumor development or progression. For example, recombinant fusion proteins consisting of the extracellular domain of the immunoregluatory proteins and the constant (Fc) domain of immunoglobulin (IgG) represent a growing class of protein ther ...

DESCRIPTION (provided by applicant): Whereas a great amount of research work has been invested into advancing transducer technology, less attention has been paid to advancing the state of reflecting surface technology beyond the use of a plane or focused mirror. Plane mirrors have understandably been the mainstay of acoustic and optical reflecting surfaces because of their ease of manufacture and ...

DESCRIPTION (provided by applicant): In the study of complex traits such as cancer, heart disease, and asthma, it is essential for investigators to have an honest estimate of required sample size when they design their studies. This is particularly true in the modern era of high-volume genetic studies, including pathway-based candidate-gene and genome-wide association studies, as they typically re ...