Award Data

DESCRIPTION (provided by applicant): The purpose of this Phase II STTR is to complete the development of a web-based training system, the All Stars Online Community. This system is designed to improve teachers' delivery of All Stars, an adolescent substance use prevention program. The goal of training is to help teachers advance in their teaching skills and understanding of underlying preventi ...

DESCRIPTION (provided by applicant): The overall goal of the proposal is to develop an automated data acquisition system for non-invasive quantitative cancer detection, screening, and monitoring, based on highly sensitive low volume real time PCR technique and capillary electrophoresis, apply this system for quantitative analysis of the telomerase activity and gene expression in single cancer c ...

DESCRIPTION (provided by applicant): Phase I Reflectance confocal microscopy images the cellular and structural morphology of tissue in-vivo or ex-vivo without the need for histological processing. Existing reflectance confocal microscopes use single wavelength laser to generate gray scale intensity images. The goals of this proposal are to build and characterize a coherence reflectance c ...

DESCRIPTION (provided by applicant): The development of novel and improved technologies for bone regeneration is desirable in many clinical applications, especially in dental and craniofacial reconstruction and fracture repair. Optimal bone regeneration requires the interaction of three components at the site of injury. These include: the presence of appropriate cell type(s) with bone regenerative ...

DESCRIPTION (provided by applicant): The long term aim of this project is to develop a novel wireless cardiac pacemaker electrode system. With the proposed technology, multiple such electrodes can be positioned at optimal sites within the coronary veins of the heart for cardiac resynchronization therapy, but require no lead wires from the pacing power source and controller. The wireless feature ...

DESCRIPTION (provided by applicant): PowerPoint(R) multimedia software is ubiquitous in our schools but its capacity for teaching children with autism spectrum and related disorders barely has been realized. This STTR (Phase I) project will begin to change this state of affairs by researching and developing empirically derived multimedia teaching tools. Encouraged by early-stage feasibility work, ...

DESCRIPTION (provided by applicant): About 250,000 Americans a year die of coronary heart disease without being hospitalized, and most of these are sudden deaths caused by cardiac arrest. Due to similarities of cardiovascular physiology and genetic structure to humans, biomedical research has increasingly employed the mouse in models of human disease, which has provided powerful tools for investig ...

DESCRIPTION (provided by applicant): Morphine and other opiate drugs are widely used to treat severe pain but the addiction and side effects they produce often limit their use. The goal of this research is to develop a novel treatment for morphine addiction and toxicity based on an endogenous peptide, glycyl-glutamine (Gly-GIn). Gly-GIn is synthesized in brain from the opioid peptide, beta-endorph ...

DESCRIPTION (provided by applicant): Quantum leaps in medicine and the biological sciences will be achieved when anatomical and functional details at multiple scales can be linked within and across subjects. The technology for capturing, managing, and reporting such details and linkages is the science of atlas formation. While images have the potential to capture micro and macro details, a ...

DESCRIPTION (provided by applicant): Celiac Sprue is an inherited disease of the intestine caused by ingestion of immunogenic peptides derived from gluten, a class of proteins present in wheat, barley and rye and therefore in many commercially available foods. Symptoms are severe, the only feasible treatment for Celiac Sprue being a strict adherence to a gluten free diet. This work seeks support f ...