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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. AAV2-ASPA-Based Metabolic Intervention for Alzheimer's Disease

    SBC: ASKLEPIOS BIOPHARMACEUTICAL, INC.            Topic: NIA

    Abstract We propose to initiate preclinical development of a gene therapeutic targeted to Alzheimer's Disease. The World Health Organization's and Alzheimer's Disease International's report on Dementia (2012) recognizes that the global burden of AlzheimerDisease is forecast to worsen significantly with prevalence predicted to double every 20 years. Interventions that could prov ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Active Control of Scramjet Isolator Shocks (ACSIS)

    SBC: Innoveering, LLC            Topic: AF15AT19

    ABSTRACT: Active control of the shock system in a scramjet engine isolator opens possibilities for enhanced engine performance and reduced engine weight by eliminating excess isolator design margin. A successful system will allow for maximum performance from a given engine configuration and will deliver range and efficiency that exceeds those possible using passive unstart control. Our approach is ...

    STTR Phase I 2015 Department of DefenseAir Force
  3. A Millimeter-wave Tunable Cavity for Ultra-sensitive Solids and Liquids DNP-NMR at Low Budget

    SBC: DOTY SCIENTIFIC, INC.            Topic: NIA

    ? DESCRIPTION (provided by applicant): NMR is probably the most powerful and widely used analytical technique for structure determination and function elucidation of molecules of all types, but it suffers from low sensitivity, particularly for insoluble biological macromolecules. Dynamic Nuclear Polarization (DNP) with Magic Angle Spinning (MAS) has recently demonstrated S/N gains exceeding t ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. A Multiscale Simulation Framework to Model Energetic Materials Subjected to Shock Loading

    SBC: SIMMETRIX, INC.            Topic: AF15AT28

    ABSTRACT: The overall objective of this project is to develop scalable simulation components that effectively model the meso-scale physics of heterogeneous energetic materials subject to dynamic shock loading including matrix debonding, void collapse, and damage due to crystal to crystal interactions, and bridges the meso-scale to the macro-scale for system scale simulations of the transition to d ...

    STTR Phase I 2015 Department of DefenseAir Force
  5. A Novel Approach to Purifying iPSC Derived Cell Cultures

    SBC: HocusLocus Inc.            Topic: 200

    DESCRIPTION provided by applicant We are pioneering an RNA based switch technology called structurally interacting RNAs sxRNA which utilizes post transcriptional gene regulation as a reporter for miRNA detection Normally RNA binding proteins RBP associate with a andapos stem loop structure to facilitate translation of an upstream coding region by as much as an order of magnitude It is ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. A novel therapeutic approach for Acute Lung Injury/ARDS

    SBC: BIOMARCK PHARMACEUTICALS, LTD            Topic: NHLBI

    DESCRIPTION (provided by applicant): The objective of the proposed project is to advance the development of novel peptides targeting MARCKS (Myristoylated Alanine-Rich C Kinase Substrate) protein as platform drug molecules for the treatment of Acute Lung Injury (ALI) and its more severe form, Acute Respiratory Distress Syndrome (ARDS), thereby providing the first pharmacologic therapeutic for this ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Automated Assessment of Leptomeningeal Collaterals on CT Angiograms

    SBC: KITWARE INC            Topic: 108

    DESCRIPTION provided by applicant The primary goal of this study is to develop an automated scoring system of leptomeningeal collaterals based on CT angiography CTA as a quantitative assessment of acute stroke Leptomeningeal collaterals provide an alternate path of blood flow in the setting of a proximal occlusion The presence and effectiveness of leptomeningeal collaterals i e andquot c ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Axonal Transport HTS Platform for Neurodegeneration Drug Discovery

    SBC: Bellbrook Labs, LLC            Topic: 106

    DESCRIPTION provided by applicant Neurodegenerative diseases that affect motor neurons such as PD ALS and HD represent an enormous unmet medical need that is growing with the aging population Existing treatments have little or no effect on the course of disease and patients have to cope with the loss of brain and body function for the rest of their lives Defects in the transport of organell ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Biological treatment of bacterial keratitis

    SBC: AMEBAGONE INC            Topic: N

    DESCRIPTION provided by applicant Staphylococcus is the most common cause of infections worldwide The pathogen persists asymptomatically on human skin from which it may spread to ocular tissues and cause corneal infection When this happens corneal bacterial keratitis can occur and if not treated effectively it may lead to blindness Multi Drug Resistant MDR variants of S aureus Sa are ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Biomimetic Material Solutions for the Stabilization of Labile Reagents

    SBC: Carrera Bioscience Inc.            Topic: AF15AT29

    ABSTRACT: A platform (PHA-fuse) for the stabilization of diagnostic and therapeutic reagents will be established based upon the polymer, polyhydroxyalkanoate (PHA). Fusions of a target molecule to PHA synthase, the enzyme responsible for PHA synthesis, will be constructed and used to catalyze the synthesis of PHA granules. These PHA granules will help stabilize the fused target molecules and elimi ...

    STTR Phase I 2015 Department of DefenseAir Force
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