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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Non-ATP competitive inhibitors of cyclin dependent kinases as cancer therapeutics

    SBC: PPI PHARMACEUTICALS, LLC            Topic: NCI

    DESCRIPTION (provided by applicant): As cancer is one of the leading causes of death in the United States with some sub-types remaining essentially untreatable, expansion of available drug targets will provide significant new options for the development ofmore effective antineoplastic agents. The major goal of this project is to apply a unique drug discovery strategy to cancer drug development. Th ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Removal of Amyloid-beta Peptides from the Alzheimer's Brain

    SBC: WE BIOSCIENCES, LLC            Topic: NIA

    DESCRIPTION (provided by applicant): As the Alzheimer's disease (AD) population is growing rapidly, currently there are no cure treatments. The goal of this resubmitted STTR proposal is to conduct a preclinical study with pramlintide to prove a potential treatment for AD. We have revised the proposal significantly according to the reviewers' comments. Pramlintide is an FDA approved drug ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Functional-selection of affinity reagents against DNA-protein complexes using targeted chromatin sequences

    SBC: AXIOMX INC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Site-specific binding of proteins to DNA plays an important role in cell development, cell signaling, the cell cycle, and diseases such as cancer. There are two overarching goals to this proposal: (1) to develop a meansfor the identification of proteins bound to specific DNA sequences, and (2) to develop a better method for the identification of immunoprecipita ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. A Millimeter-wave Tunable Cavity for Ultra-sensitive Solids and Liquids DNP-NMR at Low Budget

    SBC: DOTY SCIENTIFIC, INC.            Topic: NIA

    ? DESCRIPTION (provided by applicant): NMR is probably the most powerful and widely used analytical technique for structure determination and function elucidation of molecules of all types, but it suffers from low sensitivity, particularly for insoluble biological macromolecules. Dynamic Nuclear Polarization (DNP) with Magic Angle Spinning (MAS) has recently demonstrated S/N gains exceeding t ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Disposable paper-based electrochemical metal ion sensors for water safety testing

    SBC: ZANSORS            Topic: NIEHS

    DESCRIPTION (provided by applicant): This Phase I application aims at developing a generalizable electrochemical biosensing platform for detection of metal ions in water. Specifically, the main objective of the project is to validate the design of a convenient, cost-effective electrochemical ion (E-ION) sensing platform for direct detection of metal ion contaminants such as mercury (Hg2+), silver ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Flexible Ion-Mediated Artificial Retina

    SBC: LAMBDAVISION, INC.            Topic: NEI

    DESCRIPTION (provided by applicant): A flexible, protein-based, ion-mediated retinal implant is proposed for the restoration of vision for patients with retinal degenerative diseases, such as age-related macular degeneration (AMD) and retinitis pigmentosa(RP). The implant under development uses the retinal- containing protein, bacteriorhodopsin (BR), to convert light into a pH gradient. This gradi ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Wireless sensor patch for reducing barriers to in-home sleep apnea screening

    SBC: ZANSORS            Topic: NIMHD

    DESCRIPTION (provided by applicant): Obstructive sleep apnea (OSA) is the most common type of sleep apnea. OSA affects an estimated 18-40 million adults and 0.7-3% of all children in the US. OSA results in tiredness, depression and fatigue, and has severalassociated common comorbidities. It is believed that over 80% of OSA remains undiagnosed. Poorer and disadvantaged communities are at higher ris ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Field-Side Mobile-Device Oculomotor Function Assessment

    SBC: BARRON ASSOCIATES, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): The US Centers for Disease Control and Prevention estimate that 1.6 - 3.8 million concussions occur annually. Although striking, these figures are vast underestimates of the actual number of afflicted individuals because many who have suffered a concussion are never diagnosed because they do not seek medical advice. During competition and practice, athletes are ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. CG-GRID: Computational Genetics Grid Resource for Interaction Discovery

    SBC: PARABON COMPUTATION, INC.            Topic: 400

    DESCRIPTION provided by applicant Advances in DNA sequencing technology have now made it practical and affordable to generate datasets containing millions of genetic attributes that can be tested for association with disease susceptibility The computational complexity of searching for genetic interactions over such high dimensional datasets imposes great challenges for genome wide associatio ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. A Rapid assay for RNA targeted drugs: Instrumentation Supplement

    SBC: NUBAD, LLC            Topic: 300

    DESCRIPTION provided by applicant Some of the most significant therapies that treat disease target nucleic acids Drugs that target nucleic acid include cancer drugs antibiotics and antivirals Combined these classes of drugs have annual sales worldwide of $ billion Antibiotics that target nucleic acids account for $ billion of the $ billion of sales annuall for all antibiotics an ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
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