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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Novel Inhibitors of Pim Protein Kinases

    SBC: VORTEX BIOTECHNOLOGY CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): There is a growing body of evidence that implicates the protein kinase Pim-1 as a major driver of prostate cancer progression, and perhaps response to chemotherapy. Pim-1 is overexpressed in early prostate intraepithelial neoplasia and metastatic prostate cancer, and its levels predict response to therapy. Pim-1-overexpressing mouse prostate stem cells demonstr ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  2. A Pb-212 Generator Using Resistant Substrate and Rn Cold Trapping

    SBC: ALPHAMED, INC            Topic: N/A

    DESCRIPTION (provided by applicant): Targeted Pb-212 therapy in preclinical animal tests has shown a cure in groups receiving the highest dose of this therapy. Scaling the dose that was most efficacious in animal studies to people would bring the human dose required from 50 to 100 mCi. This application will research an approach that would provide a generator system that would support these require ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  3. Tribosupplementation of Injured Joints

    SBC: TRIBOLOGICS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Injury is a well established risk factor in the pathogenesis of osteoarthritis (OA) as supported by several large longitudinal population studies. Patients with meniscal and ACL injuries in particular are at risk for early OA. Chondroprotection of the joint surface is mediated by lubricin which forms an ordered nanofilm and provides anti-adhesion via steric rep ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  4. An Acoustic Mobility Aid for the Visually Impaired

    SBC: BIOMIMETIC SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this project is to develop a sonar system that can be used as a mobility aid by the visually impaired. The system will consist of an ultrasonic acoustic source using a waveform that is designed to optimize target discrimination and a pair of miniature microphones that are mounted near the ears to create natural interaural level and timing difference ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  5. A Nanofibrous Bioactive Prosthetic Sewing Cuff

    SBC: BIOSURFACES INC            Topic: N/A

    DESCRIPTION (provided by applicant): Cardiac valve replacement using prosthetic valves is indicated when progression of degenerative disease or bacterial infection of the native valve results in valvular dysfunction, thereby impacting on cardiac output. An estimated 50,000 prosthetic valves are implanted annually in the United States, with this number increasing due to an aging population and, to ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  6. Acid Ceramidase, Target for Cancer

    SBC: Sphingogene, Inc            Topic: N/A

    DESCRIPTION (provided by applicant): Acid ceramidase (AC) has been implicated as a novel target for cancer therapy because of its pivotal role in regulating interconversion of three key bioactive lipids; ceramide (Cer), sphingosine (Sph) and Sphingosine-1-Phosphate (S1P). It is well known that Cer functions predominantly as a tumor suppressor lipid and mediator of apoptosis following chemo and rad ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  7. A System to Analyze Facial Features to Enable Operator Condition Tracking (AFFECT)

    SBC: CHARLES RIVER ANALYTICS, INC.            Topic: A09AT006

    The duties of modern military personnel often require the completion of challenging tasks, in stressful environments, and with multiple demands competing for the warfighter’s focus. Measuring the stress, anxiety, uncertainty, and fatigue (SAUF) of the warfighter during a particular task would have multiple benefits: (1) commanders would be able to detect problems and reallocate workload or addre ...

    STTR Phase I 2009 Department of DefenseDefense Advanced Research Projects Agency
  8. Bioinformatic Generated and Learned Acute Assessment Models (BioGLAAM)

    SBC: CHARLES RIVER ANALYTICS, INC.            Topic: A09AT027

    Hemorrhagic shock remains a leading cause of death for soldiers on the battlefield. The first 60 minutes following a traumatic injury is vital to saving lives; therefore, it is critical to provide medical personnel with real time monitoring of soldiers with traumatic injuries. Recent research indicates, however, that no single measure alone is sufficient to determine the severity of hemorrhage in ...

    STTR Phase I 2009 Department of DefenseDefense Advanced Research Projects Agency
  9. Patch Clamp Amplifiers on a Chip

    SBC: HARVARD BIOSCIENCE, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The patch-clamp technique is the central tool for characterizing ion channel function. For functional genomics and for drug discovery, the ability to perform high-throughput (HTS) patch clamp recordings is urgently needed. We propose to develop an enabling technology for HTS recordings by integrating a high-performance patch-clamp amplifier into a single monoli ...

    STTR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
  10. Development of an anti-PSA IgE to treat prostate cancer

    SBC: ADVANCED IMMUNE THERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The present proposal seeks to develop a novel anti-prostate specific antigen (PSA) IgE antibody for the treatment of prostate cancer (PCA) with the goal to induce a hypersensitivity reaction to the tumor. The objective of this proposal is to generate the anti-PSA IgE and to demonstrate that this anti-PSA IgE will target the tumor by two parallel pathways: a) by ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
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