Award Data

No technology currently exists for objective assessment of handwritingeven though overmillion individuals in the United States suffer from disorders that affect handwritingincludingmillion children with dyspraxia and overolder adults with Parkinsonandapos s diseaseThis lack of assessment technology creates a barrier to effective carebecause occupational therapists cannot easily distinguish motor d ...

ABSTRACT Point of care imaging is highly desired in otolaryngologic clinics for the diagnosis of earnose and throatENTdiseases including cancersDue to limited image qualitycurrent cone beam CTCBCTproducts act not as a substitute but rather as a complement to diagnostic Multi slice CTMSCTin maxillofacial and ENT imagingThe emerging multi source x ray source technology suggests new designs of CT sys ...

ABSTRACT Transplantation is an accepted and highly successful therapy for end stage organ diseaseWhile success rates and survival have risen steadilydue largely to improved immunosuppression regimesthere is a growing appreciation that damage and inflammation that occur early in the life of the graftsignificantly impact chronic rejection and thus long term survivalCentral to these early event injur ...

PROJECT SUMMARY ABSTRACT More people die every year from kidney disease than breast or prostate cancerKidney transplantation is life saving but is limited by a shortage of organ donors and an unacceptably high donor organ discard rateThe decision to use or discard a donor kidney relies heavily on manual quantitation of key microscopic findings by pathologistsA major limitation of this microscopic ...

PROJECT SUMMARYfluorouracilFUhas been the first choice chemotherapy drug for colorectal cancerCRCfor many yearshoweverits clinical utility remains hindered by hematopoietic and gastrointestinal toxicities resulting from its non selectivitySide effects include fatigueloss of appetiteand diarrhea among othersall of which can lead to reduced quality of lifeThe economic burden associated with chemothe ...

Project Summary and Abstract Falls are the leading cause of death due to injuryThis simple motion is so common thatof community dwelling older adultsandof long term care facilities will experience a fall in the coming yearThe risk of falling substantially increases for those having Alzheimer s disease and related dementiasand those with Parkinson s diseaseThe financial burden is significant with f ...

NuPeak Therapeutics Incis a biotechnology start up companyC corporationdesigned to deliver a first inclass small molecule kinase inhibitorThe present Project is aimed at an inhibitor for treatment of breast cancerwhich remains a leading cause of morbidity and mortality in the U Sdespite current therapeutic approachesIn that contextwe identified a novel typeimmune response that activates mitogen ac ...

Project Summary Arch Innotek proposes to develop a sustainablecost effective fermentation process to produce lutein using engineered yeastLutein is an important antioxidant compound that can slow the progression of vision loss caused by age related macular degenerationAMDcataractsand retinitis pigmentosaAside from protecting eyesdietary intake of lutein can reduce risk of skin disordersseveral typ ...

AbstractNoise is the number one occupational and environmental hazardand noiseinduced hearing lossNIHLis one common form of sensorineural hearing deficitonly second to age related hearing lossCurrently no drug preventing NIHL is approved by the United States Food and Drug AdministrationFDAOne major challenge for the introduction of such interventions is the need to identify appropriate human popul ...

AbstractSmart Sensor Bandage for Ulcer Monitoring Non healing pressure ulcers result in approximately $billion in additional treatments each year in the United Statesraising in hospital mortality by nearly threefold and lengthening hospital stay by more than double when ulcers are presentThis burden is particularly pronounced in assisted living facilities where occurrence is high and skilled nursi ...