Award Data

DESCRIPTION (provided by applicant): The Ras oncogene is one of the most frequently mutated oncogenes in human cancers. Active Ras mutation is strongly associated with human cancers. Extensive efforts have been made to identify Ras inhibitor as a putative cancer therapy with the most promising progress made on the development of farnesyltransferase inhibitors. However, ...

DESCRIPTION (provided by applicant): BioInVision, Inc. and Case Western Reserve University researchers will develop a cryo-imaging system for 3D imaging of mice. It will serve very many applications in biological research and the biotechnology industry, in cluding mouse anatomical phenotyping, drug delivery, imaging agents, metastastic cancer, pathogen/immune system response, and stem cells/regene ...

This proposal is in response to the DOE topic 12a on membrane technology, which represents an important method in water purification and recovery for industrial and environmental applications. Energy-related cost and water waste are significant issues with reverse osmosis (RO) membrane commonly used today and increased attention is being given to Nano-filtration (NF) technology. NF covers treatmen ...

PROJECT SUMMARY Vitiligo is the most common acquired hypopigmentary disorder that afflicts 0.5-2% of the world population, from all ethnicities and skin color. It is characterized by loss of melanocytes, which is often progressive, resulting in depigmented skin lesions. Vitiligo can be segmental (5-16% of all cases) or most commonly, non-segmental. It is a disease of young adults, as 25% of all no ...

Due to huge levels of computing parallelism and higher performance per watt, comuting accelerators are crucial for increasing HPC efficiency. This is economically significant for small and medium size manufacturing companies (SMMs) and essential for transition to Exascale computing. However, due to high procurement costs, in-house maintenance of an accelerated HPC cluster is prohibitive for many ...

High-energy physics, modern medicine and advanced materials research are continually demanding higher magnetic fields. In spite of the discovery of High Temperature Superconductors decades ago and the potential they have for high field use, until recently successful magnets using the technology have remained elusive. Great progress has been made recently in HTS wire performance and this has drawn ...

Hig e and advanced materials are continually demanding higher magnetic fields. Efforts to generate fields in excess of 25 Tesla have been a principal driver of high temperature superconductor research. Although HTS materials were discovered decades ago and have always shown significant potential for high field use, until recently magnets using the technology have remained elusive. Great progress h ...

High energy physics research, modern medicine and advanced materials are continually demanding stronger magnetic fields. Efforts to generate fields in excess of 25 Tesla have been a principal driver of High Temperature Superconductor research. Although HTS materials were discovered decades ago and have always shown significant potential for high field use, until recently magnets using the technolo ...

High energy physics research, modern medicine and advanced materials are continually demanding stronger magnetic fields. Efforts to generate fields in excess of 25 Tesla have been a principal driver of High Temperature Superconductor research. Although HTS materials were discovered decades ago and have always shown significant potential for high field use, until recently magnets using the technolo ...

The majority of hybrid electric vehicles and electric vehicles (HEV/EV) products use interior permanent magnet (IPM) synchronous machines for traction purpose due to the efficiency and power density consideration. IPM machines use high energy density rare earth based magnet materials such as neodymium and dysprosium. Variable flux (VF) machines using abundant and cheaper soft magnets such as AlNiC ...