Award Data

Project Summary As a participant in the new IDeA Regional Entrepreneurship Development (I-RED) program, the goal of this proposal is to create an educational product to promote entrepreneurism and commercialization in the Mountain West region of IDeA states. The educational product and overall program are intended to address the needs of IDeA state academic institutions in developing and strengthe ...

SummaryResting-state functional MRI (rsfMRI) is a rapidly developing task-free approach for presurgical mapping. It can complement task-based functional MRI (tfMRI) in patients who have difficulties performing tasks and efficiently map resting state networks (RSNs) in regions that are not typically mapped with tfMRI due to time constraints, such as frontal cortex. It has the potential to provide i ...

PROJECT SUMMARY We propose to develop a novel non-contact, label-free multimodality imager that provides real-time intraoperative identification of nerves within the surgical field-of-view to facilitate the prevention of unintended nerve damage (termed iatrogenic nerve injury) during surgical procedures, as they are a major source of postsurgical complications, e.g., chronic pain. In the United St ...

Abstract There is an unmet need to develop treatments for senile osteoporosis, a disorder characterized by an age-related reciprocal decrease in osteogenesis and increase in bone marrow fat. Senile osteoporosis resembles disuse osteopenia, suggesting its pathogenesis involves impaired bone mechanosensing. We discovered that the polycystin heterotrimeric complex (1PC1+3PC2) functions as a mechanose ...

1 PROJECT SUMMARY2 Humans are living longer, resulting in our bodies outliving our brains. Although behavioral changes and better3 management of health conditions can help reverse or slow down premature decline in brain function, pre-4 symptomatic adults are not identified early enough when these changes would make the most significant positive5 impact. Effective intervention requires early detect ...

Project SummaryEpilepsy is one of the most common brain disorders. Current drugs have limited efficacy. Identifying new targeted drugs that can be used as safer, more effective therapies is in urgent unmet need. Selective inhibition of the transient receptor potential canonical 3 (TRPC3) emerges as a novel strategy to impede epilepsy. However, the currently best selective TRPC3 inhibitor, Pyr3, ha ...

The modern space environment is dynamic and contested, requiring constant surveillance to detect maneuvers and thwart malicious intents. Modern maneuver detection techniques rely on either increasing solution noise or estimating maneuvers by propagating multiple models. Both suffer during long data gaps or in cluttered environments, thereby yielding inconsistent results in proliferated orbital reg ...

Tau Technologies’ proposed approach is based on a single-ended eye-safe pulsed laser Rayleigh guide star source with the employment of an SLM (Spatial Light Modulator) to form a dynamic Hartman-Shack turbulence sensor.  This system results in turbulence s

The smart contact lens application presents several unique challenges to successfully produce functional circuitry on the contact lens surface.  These complex-shaped, flexible substrates limit the use of traditional, mature electronic manufacturing approa

Electromagnetic Interface (EMI) Shielding is critical for maintenance of critical infrastructure and to prevent from external signals from disrupting electronics devices.  State of the art EMI shielding includes heavy metal-based materials, which add mass