Award Data

Project Summary A Chemiluminescent Assay and Device for Monitoring Vascular Endogenous Nitric Oxide This STTR Phase I project aims to establish the feasibility of a novel chemiluminescent assay for the detection of nitric oxide in blood. Phase II will aim to use this assay in a point-of-care device to measure vascular endogenous nitric oxide (VeNO) from a finger-prick of blood for ultimate deploym ...

Project Summary Technology advances now enable the cost effective acquisition of Kandgt distinct data types from a common set of N bio samples where i the kth data type is represented by a data matrix with columns containing Pk measurements in N samples for k K and ii at least one of the data types is big i e Pk is much bigger than N for some k The rapid accumulation of such mult ...

This Phase II STTR proposal describes an activated form of organophosphate hydrolyzing enzyme that, when dissolved in water, forms a covalent bond to skin. In Phase I, a lyophilized preparation of Organophosphate Hydrolase (OPH) from Pseudomonas diminutaretained the capability to couple to skin and to hydrolyze nerve agent surrogates when stored for months at 40¿C. Immobilized enzyme also retai ...

This Phase II STTR proposal describes an activated form of organophosphate hydrolyzing enzyme that, when dissolved in water, forms a covalent bond to skin. In Phase I, a lyophilized preparation of Organophosphate Hydrolase (OPH) from Pseudomonas diminutaretained the capability to couple to skin and to hydrolyze nerve agent surrogates when stored for months at 40¿C. Immobilized enzyme also retai ...

The current produced in electrochemical galvanic cells is primarily dependent on the rate of the electrode reactions where the cell's anode is less negative, supplying less energy than thermodynamically predicted, and the cell's cathode is less positive, supplying less energy than thermodynamically predicted. Reduction of electrochemical overpotentials in electrochemical systems has been the prim ...

he current produced in electrochemical galvanic cells is primarily dependent on the rate of the electrode reactions where the cell's anode is less negative, supplying less energy than thermodynamically predicted, and the cell's cathode is less positive, supplying less energy than thermodynamically predicted. Reduction of electrochemical overpotentials in electrochemical systems has been ...

DESCRIPTION (Scanned from the Applicant's Abstract): Obesity is a major risk factor for diabetes mellitus (type 2; NIDDM). Fat cells secrete both diabetes promoting molecules (fatty acids; TNF-alpha) and at least one molecule that may be antidiabetic (leptin). We have partially purified a new protein (cytokine) which is also secreted by mature adipocytes, Adipocyte Diffe ...

DESCRIPTION (provided by applicant): The indications for androgen therapy has expanded such that today, androgens are used in both men and women, and in addition to their use in treating primary (or secondary) hypogonadism the potential benefit of increasing bone mineral density, inducing greater muscle mass and strength, enhancing sexual function, and improving mood. Androgens are also being cons ...

In recent years, the military has been integrating robotic systems into tasks previously performed entirely manually by soldiers. Examples include explosive ordnance disposal (EOD), surveillance and reconnaissance, urban search and rescue (USAR), chemical, biological, and nuclear (CBN) operations, and medical assistance and evacuation. A typical application is for a soldier (remote operator) to te ...

DESCRIPTION (provided by applicant): The ability to create new cardiac tissue using progenitor cells via engraftment would be a significant advance. However, the existing types of progenitor cells presently in Phase I clinical trials face significant limitations, including lack of evidence that the donor cells (1) produce new cardiac myocytes, versus creating benefits via neoangiogenesis or ventr ...