Award Data

DESCRIPTION (provided by applicant): Molecular interactions form the foundation of biology and chemistry. They are central to life itself and determine catalytic activity, cellular function, and therapeutic efficacy. The vast majority of diagnostic procedures depend on some type of specific molecular interaction. Therefore, the ability to perform pure liquid-phase molecular binding analysis at hi ...

DESCRIPTION (provided by applicant): Deep brain stimulation has risen as a neurosurgical procedure of choice for patients with disabling neurological or psychiatric disorders for its abiliy to modulate improvement in the activity of certain circuits. The procedure is currently approved for treatment of Parkinson's disease (PD), essential tremor (ET), dystonia, and obsessive-compulsive disorde ...

The DoD has identified a need to develop radiation hardened electronic components capable of surviving and operating through exposure to radiation environments encountered in space. To protect these electronic components, systems typically employ a combination of methods for radiation protection. International FemtoScience (FemtoSci) proposes a practical solution to produce Inherently Radiation Ha ...

A space-saving, economical, collapsible alternative to rigid sunshades-and particularly a replacement for beryllium sunshades-for the protection of optical coatings and heat seeking sensors on kinetic kill vehicles and similar equipment. The bellows sunshade is a self-deploying, non-toxic, titanium, all metallic, non-outgassing cylindrical shield that can expand up to twelve times its stowed leng ...

Because of its high sensitivitypolymerase chain reactionPCRis the gold standard for the diagnosis of many infectious diseasesbut generally only implemented in well equipped laboratoriesOne of the major roadblocks for expanding PCR to point of care markets is the lack of simplerobustsingle tube PCR designs which preserve its laboratory based high sensitivity and specificityIn this Fast Track STTR a ...

Expressing humanized bacterial luciferase in stem cellsMoving beyond firefly luciferase toexpand the informational capacity of animal models for regenerative medicine Project Summary This Small Business Technology TransferSTTRPhase II project proposes to develop complementary autonomously bioluminescentautobioluminescentin vitro stem cell lines and in vivo small animal model systems that enable th ...

Solid oxide fuel cells have long suffered from degradation due to impurities in the fuel and complexities associated with dissimilar materials and high operating temperatures. This degradation lowers the usable cell power output and requires ancillary equipment for fuel sulfur removal and reformation. A unique microstructure for a tubular anode-supported SOFC is being developed using a novel freez ...

Solid oxide fuel cells have long suffered from degradation due to impurities in the fuel and complexities associated with dissimilar materials and high operating temperatures.This degradation lowers the usable cell power output and requires ancillary equipment for fuel sulfur removal and reformation.A unique microstructure for the tubular anode will be produced using a novel freeze-casting techniq ...

DESCRIPTION (provided by applicant): Autoimmune diseases are thought to arise from abnormalities in innate or adaptive immune responses and most likely have both genetic and environmental components. Diagnosis of autoimmune disease is often difficult, as t he symptoms can be relatively nonspecific. Furthermore, no available blood test can accurately exclude the possibility of an autoimmune disease ...

DESCRIPTION (provided by applicant): Autoimmune diseases are difficult to diagnose, as the symptoms can be nonspecific. A single test that could readily distinguish between an autoimmune and non-autoimmune disorder would allow physicians to focus efforts on the specific disease that affects the patient. This is critical for diabetes mellitus (DM), which has two subsets, Type I and Type II. The sub ...