Award Data

DESCRIPTION (provided by applicant): Mucopolysaccharidosis type I (MPS I) is an autosomal recessive storage disease caused by the absence of a-L-iduronidase (IDUA), resulting in systemic accumulation of glycosaminoglycan (GAG) storage materials, hepatosplenomegaly, skeletal dysplasias, cardiopulmonary obstruction, progressive neurologic impairment and death by age 15. MPS I is currently treated b ...

DESCRIPTION (provided by applicant): Our long-term research goal is to develop an ophthalmic, nanofiber-based, biodegradable device that will provide extended release of therapeutic agents to the posterior segment of the eye via transscleral and intravitr eal approaches. This platform device will address the major technical problem in the treatment of posterior eye diseases (diabetic retinopathy, ...

This project produces a new, accessible, web-based I Can Work application that enhances community participation and independent living for individuals with disabilities. Individuals with disabilities who are receiving Social Security Disability Insurance (SSDI) and Supplemental Security Income (SSI) often need to work to supplement their disability benefits. Increases in earned income ...

Use of a new noninvasive test for the accurate early detection of preeclampsia is proposed as a tool to screen women during early stages of pregnancy. Preeclampsia affects 10% of the 4 million pregnancies in the U.S. each year and is the leading cause of maternal and neonatal medical complications and death. There is currently no means of detecting preeclampsia prior to onset of clinical symptoms ...

THE POOR PERFORMANCE OF STUDENTS WITH DISABILITIES ON TESTS DESIGNED FOR THE NON-HANDICAPPED HAS LONG BEEN A CONCERN OF SPECIAL EDUCATORS. SPECIAL EDUCATION STUDENTS MAY BE PENALIZED BY THE FORMAT AND PRESENTATION OF TEST ITEMS AND BY CONDITIONS UNDER WHICH THE TESTS ARE ADMINISTERED. RESEARCH INDICATES THAT LOW PERFORMANCE OF STUDENTS WITH DISABILITIES ON MINIMUM COMPETENCY TESTS IS A PARTICULARL ...

FINDING AND DISABLING A BALLISTIC MISSILE IN FLIGHT REQUIRES THE COORDINATION OF MANY, TIGHTLY INTEGRATED FUNCTIONAL ELEMENTS. TRADITIONALLY, SUCH SYSTEMS ARE DESIGNED AS INDEPENDENT COMPONENTS WITH CLEARLY DEFINED INTERFACES, SO THAT THERE IS A CLEAR SEPARATION BETWEEN MODULE AND CLIENT. SUCH SYSTEMS PASS DATA TO EACH OTHER BUT DO NOT OTHERWISE COLLABORATE IN THE OVERALL SYSTEM GOALS. THEY ALSO A ...

DESCRIPTION (provided by applicant): Anastomotic failure is one of the most feared complications of gastrointestinal surgery due to the resultant morbidity and mortality. Failure of an anastomosis, or intestinal junction, can cause a spectrum of morbidities to the patient including local abscess formation - requiring procedural drainage, tumor recurrence, debilitating pain, dysfunctional defecatio ...

DESCRIPTION (provided by applicant): Approximately 30,000 people in the United States are diagnosed each year with pancreatic Cancer (PanCa). Over 90% of these will die of the disease making PanCa one of the most devastating human malignancies. The current 5-year survival rate of less than 4% has changed little in the last 20 years despite improvements in therapy including the introduction of chem ...

DESCRIPTION (provided by applicant): Approximately 30,000 people in the United States are diagnosed each year with pancreatic cancer (PanCa). Over 90% of these will die of the disease making PanCa one of the most devastating human malignancies. The current 5-year survival rate of less than 4% has changed little in the last 20 years despite improvements in therapy including the introduction of ...

DESCRIPTION (provided by applicant): Approximately 30,000 people in the United States are diagnosed each year with pancreatic cancer (PanCa). Over 90% of these will die of the disease making PanCa one of the most devastating human malignancies. The c