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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. AAV Mediated Gene Transfer to the CNS for MPS I

    SBC: REGENX BIOSCIENCES, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Mucopolysaccharidosis type I (MPS I) is an autosomal recessive storage disease caused by the absence of a-L-iduronidase (IDUA), resulting in systemic accumulation of glycosaminoglycan (GAG) storage materials, hepatosplenomegaly, skeletal dysplasias, cardiopulmonary obstruction, progressive neurologic impairment and death by age 15. MPS I is currently treated b ...

    STTR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  2. A Dual Molecular/Targeting Therapy for PanCa

    SBC: SYNERGENE THERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Approximately 30,000 people in the United States are diagnosed each year with pancreatic Cancer (PanCa). Over 90% of these will die of the disease making PanCa one of the most devastating human malignancies. The current 5-year survival rate of less than 4% has changed little in the last 20 years despite improvements in therapy including the introduction of chem ...

    STTR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  3. A Dual Molecular/Tumor Targeting Therapy for PanCa

    SBC: SYNERGENE THERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Approximately 30,000 people in the United States are diagnosed each year with pancreatic cancer (PanCa). Over 90% of these will die of the disease making PanCa one of the most devastating human malignancies. The current 5-year survival rate of less than 4% has changed little in the last 20 years despite improvements in therapy including the introduction of ...

    STTR Phase II 2004 Department of Health and Human ServicesNational Institutes of Health
  4. Advanced Infrared (IR) Sensor Components for Missile Defense

    SBC: NANO LIGHT            Topic: MDA06T011

    The objective of this proposal is to further explore PbSnSe detector array on Si substrate. Two approaches are proposed. One is a zero-risk incremental advance that employs a new growth condition to reduce the dislocation density. Another approach is a novel fabrication technique with high-risk but it could enable revolutionary rather than evolutionary advances. IV-VI semiconductors such as Pb1-x ...

    STTR Phase I 2006 Department of DefenseMissile Defense Agency
  5. Advanced Infrared (IR) Sensor Components for Missile Defense

    SBC: NANO LIGHT            Topic: MDA06T011

    The objective of this proposal is to further develop IV-VI PbSnSe detectors epitaxially grown on Si substrates. The motivation of fabricating IV-VI detector arrays on Si is based on the following advantages of IV-VI Pb-salt semiconductors. (1) The large dielectric constant helps screen and localize the defect related effects. (2) The epitaxial material on Si is highly uniform, and thus the cutoff ...

    STTR Phase II 2007 Department of DefenseMissile Defense Agency
  6. A Low-Code Hosting Environment For Virtual Embedded Hardware

    SBC: Embeddetech, Inc.            Topic: MDA19T007

    In this proposed effort, Embeddetech identifies its general-purpose ‘low-code’ platform architecture as the ideal architectural choice to support hardware virtualization, after extensive market research and experimental development. The architecture provides a flexible hosting environment for target code dynamically executing on multiple simulated processors, executing in real time. Each simul ...

    STTR Phase I 2020 Department of DefenseMissile Defense Agency
  7. Alpha-1 Antitrypsin Gene Therapy for Cystic Fibrosis

    SBC: Generx+, Inc.            Topic: N/A

    DESCRIPTION (Applicant's Abstract): The investigators have developed a plasmid vector that expresses the normal human alpha-1 antitrypsin (AAT) gene in human respiratory epithelium when delivered as a plasmid-cationic liposome complex. In subjects with inherited AAT deficiency, they showed that liposome mediated transfer of the normal AAT gene to the nasal respiratory epi ...

    STTR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
  8. An Advanced Biosensor for Molecular Interaction Studies

    SBC: MOLECULAR SENSING, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Molecular interactions are central to the understanding of basic biology and cellular function, are paramount to all molecular assays (research and in vitro diagnostics), are essential in biomarker discovery and critical toward evaluating therapeutics. However, the tools available to quantify these interactions have limitations, in so far as they either rely up ...

    STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  9. An Advanced Biosensor for Molecular Interaction Studies.

    SBC: MOLECULAR SENSING, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Molecular interactions form the foundation of biology and chemistry. They are central to life itself and determine catalytic activity, cellular function, and therapeutic efficacy. The vast majority of diagnostic procedures depend on some type of specific molecular interaction. Therefore, the ability to perform pure liquid-phase molecular binding analysis at hi ...

    STTR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  10. Analytics-Based Platform for Diabetic Retinopathy Care Management

    SBC: RETINAL CARE INC            Topic: NEI

    ABSTRACT Despite the overefficacy of diabetic retinopathyDRtreatmentit continues to be the leading cause of blindness in working age AmericansOvermillion adults in the US have diabetesOf thesewill develop DR andwill develop vision threatening DRVTDRCurrentlyless than half of all patients with diabetes receive the recommended annual dilated eye exam andof those diagnosed with VTDRonlyundergo timely ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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