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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. A digital brain-gut therapy platform for enhanced management of Irritable Bowel Syndrome

    SBC: METAME HEALTH,INC            Topic: R

    Project Summary Abstract Irritable Bowel Syndrome IBS is a chronic and costly digestive condition characterized by abdominal pain and altered bowel habits diarrhea constipation or mixed type IBS is a disorder of brain gut dysregulation including the amplification of normal gut signals at the level of the brain Yet most medical therapies for IBS to date have focused on symptom management and dietar ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Advanced Multi-Modal Wearable Sensing for the Prediction of Pre-Term Labor

    SBC: Sonica LLC            Topic: NICHD

    Preterm birthPTBdelivery prior toweeks gestational ageaccounts forof all births and remains the leading cause of neonatal deathThe majority of PTB is preceded by spontaneous preterm laborPTLCurrentlythere is a major unmet need for methods to identify women at risk of PTL and provide an early warning system for potential interventionhome uterine monitoringHUMis one approach that has shown some prom ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Albumin Nanoparticles Incorporating Piceatannol (PANPs) for ALI/ARDS therapy

    SBC: Nano Biotherapeutics, Inc.            Topic: NHLBI

    Sepsis induced ALI ARDS is a devastating syndrome of acute respiratory failure in critically ill patients that accounts for among the highest admission rates in ICU and mortalityDuring STTR Phasewe at Cell Biologics Incdemonstrated that piceatannola naturally occurring anti inflammatory that selectively inhibits Syk tyrosine kinasewhen entrapped in innm albumin nanoparticlesPANPswas therapeuticall ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Aminomethyl benzamides as novel anti Ebola agents

    SBC: Chicago Biosolutions, Inc.            Topic: NIAID

    Ebola EBOV and Marburg MARV viruses belong to the family Filoviridae and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction with an incubation period of days Because of the safety concerns these viruses are designated as the biosafety level agents Currently there is no effective vaccine or therapeutic treatment against filoviral infection and pathogenes ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. 4-(Aminomethyl) benzamides as novel anti-Ebola agents

    SBC: Chicago Biosolutions, Inc.            Topic: NIAID

    EbolaEBOVand MarburgMARVviruses belong to the Filoviridae family and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction after an incubation period ofdaysDue to safety concernsthese viruses are designated as biosafety levelagentsCurrentlythere is no effective vaccine or therapeutic treatment for filoviral infections in humansAfrica has recentlysuffered a lethal EBOV e ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Aminopiperidines as novel anti influenza agents

    SBC: Chicago Biosolutions, Inc.            Topic: NIAID

    Influenza A viruses belong to the orthomyxoviridae family with a negative sense segmented RNA genome which can cause seasonal or pandemic flu with high morbidity and significant mortality Vaccination is the most prevalent prophylactic means for controlling influenza infections However an effective vaccine usually takes at least months to develop for the circulating strains Furthermore vac ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. A Multi-Fuctional Optical Switch: A WDM, Add/Drop Multiple

    SBC: Shayda Technologies, Inc.            Topic: N/A

    The rising demand for the Internet ls driving the telecommunication! industry to an all-optical network architecture. To meet the requirements of this strategy further development and improvement of the components are necessary. Currently the commercially available photonic devices, including Wavelength Division Multiplexers (WDM's) - widely regarded as a crucial building block of the anticipated ...

    STTR Phase I 1998 Department of DefenseMissile Defense Agency
  8. A novel glutaminase-free mammalian asparaginase with minimized immunogenicity to enable expanded use in cancer therapy

    SBC: Enzyme by Design Inc.            Topic: 102

    PROJECT SUMMARY Enzyme by DesignIncEbDis developing a safer version of L asparaginase that can be used routinely in the treatment of adult ALL patients whose hypersensitivity to todayandapos s bacterial L asparaginases deprives them from this efficacious therapyEbDandapos s L asparaginase is novel due to its mammalianguinea pigorigin and its lack of L glutaminase co activityThe need for better the ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. An Ultra filtrate perfusion bio artificial pancreas for high-density islet replacement without immunosuppression

    SBC: Norfolk Medical Products, INC.            Topic: NIDDK

    DESCRIPTION provided by applicant The Cell SafeTM is a fundamentally new approach in replacement of dysfunctional insulin producing cells in patients with diabetes by transplantation of new islets in a three dimensional scaffold embedded in a highly compatible bioengineered perfusion system that continuously supplies tissue fluid blood ultrafiltrate so that the cells ae protected from immun ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Array Based Affinity Selection

    SBC: Tango Biosciences Inc.            Topic: 300

    Project SummaryAffinity reagents are useful tools for detectingmonitoringand quantifying individual proteins in complex mixturesModern recombinant biology and protein engineering techniques generate highaffinityhigh specificity reagents that overcome some of the limitations of polyclonal and monoclonal antibodiesHoweverlimited availability of target proteini eantigenprevents the selection of recom ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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