Award Data

DESCRIPTION (provided by applicant): Molecular interactions are central to the understanding of basic biology and cellular function, are paramount to all molecular assays (research and in vitro diagnostics), are essential in biomarker discovery and critical toward evaluating therapeutics. However, the tools available to quantify these interactions have limitations, in so far as they either rely up ...

DESCRIPTION (provided by applicant): Disorders of the central nervous system such as spasticity involve both neurological and muscular changes. In clinic, spasticity is routinely evaluated using the Ashworth scale and tendon reflex scale. In general, tendon reflexes have been widely used to evaluate neurological state and diagnose various neurological disorders including stroke, spinal cord injuri ...

DESCRIPTION (provided by applicant): The education reform initiative, No Child Left Behind Act of 2001 (NCLBA) signed into law by President Bush in January of 2002, emphasized the critical role of literacy in the lives of all children. Writing is an important, but often neglected, part of literacy instruction. Software tools that support the needs of a beginning writer, especially those with speci ...

A collaborative effort is proposed between IllinoisRocstar LLC and the University of Illinois to develop and commercialize a computational framework to investigate nozzle erosion in solid-propellant rocket motors (SRM) and tangential instability modes in liquid rocket engines (LRE). For SRM, highly resolved simulations will be performed to understand the effects of turbulent inlet conditions, as w ...

DESCRIPTION (provided by applicant): An absence of age-appropriate assessment technologies has hindered the ability of health, mental health, and school psychology professional to obtain and utilize self- report information from young children. This gap is problematic for science and applied fields in many ways. For example, there has been a serious under-identification of young children with inte ...

DESCRIPTION (provided by applicant): Islet transplantation (ITx), especially with the emerging potential of xenotransplantation, holds significant promise for the treatment of type 1 diabetes (T1D). There are, however, major challenges that remain prior to its larger scale, cost-effective application. Hypoxia is a leading stress post-transplantation and is estimated to cause the death of approxima ...

The deployment of next generation focal plane arrays sensing in the long wavelength infrared will improve the detection capabilities in all major MDA infrared systems. However, a major limitation to the employment of these high sensitivity arrays is the cooling system. Current tactical cryocoolers cannot meet the desired temperature requirements. The goal of this project is to develop the technolo ...

DESCRIPTION (provided by applicant): Cardiovascular disease is the leading cause of death worldwide. Current therapies for cardiovascular disease are associated with partial success, restricted access, delays, possible neurotoxicity and other important limitations. Our goal is to develop a novel therapeutic agent that is safer and more effective at dissolving the blood clots (thrombi) that cause h ...

DESCRIPTION (provided by applicant): The SENSIMMER Virtual Phaco Trainer for Cataract Surgery is a hardware and software solution aimed at a worldwide market of ophthalmology residency programs (including 118 programs in the US). It is developed by the US small business concern ImmersiveTouch-Sensimmer Inc. (Westmont, IL), in collaboration with the surgery simulation team at the University of Ill ...

The UCDS process uses a rigorous theoretical model to understand the dynamics of combustion instability. In addition to predicting the amplitude of pressure oscillations, UCDS provides clear insight into why a propulsion device oscillates. To enhance and optimize UCDS for missile defense applications, GTL proposes to refine the UCDS unsteady combustion model to capture the special features of mon ...