Award Data

Project Abstract Active surveillance (AS) is becoming more accepted as a reasonable treatment option for men with low-risk prostate cancer (i.e. Gleason score 6, clinical stage T2a, PSA lt 10). Many AS protocols at major institutions call for a prostate saturation biopsy after initial diagnosis to confirm that the patient has no areas of higher-risk prostate cancer. For most patients who underwent ...

DESCRIPTION (provided by applicant): The cryptophycins are a structurally diverse class of polyketide/non-ribosomal peptide natural products that possess potent anticancer activity. However, despite this impressive activity, the development of the cryptophycins into a beneficial cancer chemotherapeutic agent has suffered from clinically significant neurotoxicity that correlates with treatment. Non ...

DESCRIPTION (provided by applicant): The objective of this Phase I grant is to develop and test a compact cardiopulmonary support device (CCSD). This device pumps, transfers gas, and warms blood. The CCSD is attached to the patient via venovenous (VV) or v enoarterial (VA) cannulation and supplies respiratory support like extra-corporeal membrane oxygenation (ECMO) and pulsatile cardiac support si ...

The objective of this proposal is to further explore PbSnSe detector array on Si substrate. Two approaches are proposed. One is a zero-risk incremental advance that employs a new growth condition to reduce the dislocation density. Another approach is a novel fabrication technique with high-risk but it could enable revolutionary rather than evolutionary advances. IV-VI semiconductors such as Pb1-x ...

The objective of this proposal is to further develop IV-VI PbSnSe detectors epitaxially grown on Si substrates. The motivation of fabricating IV-VI detector arrays on Si is based on the following advantages of IV-VI Pb-salt semiconductors. (1) The large dielectric constant helps screen and localize the defect related effects. (2) The epitaxial material on Si is highly uniform, and thus the cutoff ...

DESCRIPTION (provided by applicant): We propose a novel and competitive urinary tract silicone Foley catheter made from a proprietary polymeric formulation to effectively reduce catheter-associated urinary tract infections (CAUTI) via nitric oxide (NO) release. Preliminary studies show that the device will be able to: (1) continuously deliver NO at rates enough to maintain bactericidal properties ...

DESCRIPTION provided by applicant In Phase I Biocrede developed a completely new urinary tract silicone Foley catheter with a andgt month shelf life made from a proprietary polymeric formulation to effectively reduce catheter associated urinary tract infections CAUTI via nitric oxide NO release for andgt weeks Key features of the new technology include catheters continuously d ...

DESCRIPTION (provided by applicant): Patient Provider Communications will develop EloquenceTM based on data acquired from research conducted by the University of Michigan School of Nursing addressing the specific aims and hypothesis. This project extends the research team's preliminary findings on the development of technology to improve communication with critically ill patients using patient des ...

DESCRIPTION (provided by applicant): Current nurse call systems lack patient-centric interfaces (i.e. pillow speakers) and the ability to relay specific requests to the most appropriat providers, which negatively impacts operational efficiency. Further, existing systems neither provide a means for limited English proficiency (LEP) patients to make call requests in their native language nor the abi ...

In this proposed effort, Embeddetech identifies its general-purpose ‘low-code’ platform architecture as the ideal architectural choice to support hardware virtualization, after extensive market research and experimental development. The architecture provides a flexible hosting environment for target code dynamically executing on multiple simulated processors, executing in real time. Each simul ...