Award Data

The IAN Team, unique in its exceptional experience in EMP protection, materials science, microgrid development and management of industrial facilities needed by DCI, proposes to develop innovative strategies and methodologies for DCI island-mode operations in the event of power grid disruption or failure due to an EM threat.These island mode operations will be supported by advanced EMP shielding m ...

Project Summary This proposal addresses the NICHD focus of specific interest for the prevention of child abuse and neglect in at risk populations Child abuse and neglect often confers short and long term impairment of the physical emotional and cognitive development of children The proposed project builds on promising data from previous randomized control trials based on application of a scr ...

DESCRIPTION provided by applicant In this Phase I SBIR project Technology Assessment andamp Transfer Inc TAandamp T and their collaborator propose development of ceramic additive manufacturing aka D printing for production of high performance ceramic dental restorations in the dental laboratory environment A ceramic additive manufacturing approach to fabricating dental restorations ha ...

DESCRIPTIONprovided by applicantThe world needs a highly effective malaria vaccineSanaria rPfSPZ Vaccinecomposed of asepticpurifiedcryopreserved radiation attenuated PfSPZprotectedof volunteers in an NIH clinical trialThe vaccine has been administered by direct venous inoculationDVItosubjects in MaliTanzaniaEquatorial GuineaEGand USASafetytolerabilityhigh grade protectionheterologous protection af ...

A NEW HOLOGRAPHIC D CAMERA FOR FUNDUS IMAGING Abstract In the United States retinal disease is the most common cause of visual impairment with age related macular degeneration AMD and diabetic retinopathy DR being the most common retinal diseases For each of the above conditions high resolution and three dimensional D imaging of the retina retinal vasculature choroid and or retinal ...

DESCRIPTION provided by applicant We propose to develop ML a small molecule PKM M isoform of pyruvate kinase activator into a new targeted therapeutic for Acute Myeloid Leukemia AML The majority of AML cases is diagnosed in adults and incidence increases significantly among elderly population The outcomes for adults with AML are poor Although chemotherapy results in high r ...

ABSTRACT Diabetes is the leading cause of nontraumatic lower extremity amputations in the United States Diabetic foot ulcers DFUs are responsible for more hospitalizations than any other diabetic complications Currently even the best available treatments achieve only a healing rate for these wounds and this healing is often only temporary with a chance of recurring Our company has ...

DESCRIPTION provided by applicant ParaTechs Corporation aims to provide researchers with advanced technology and methods to simplify procedures for laboratory animal models While actively supporting efforts to `reduce replace and refineandapos animal use ParaTechs provides safe and efficient alternatives for surgical procedures We have already brought to market a nonsurgical embryo transfe ...

DESCRIPTION Preclinical animal research is critical for driving and setting the conceptual framework for subsequent clinical trials and the establishment of new and novel therapeutic approaches However preclinical studies are frequently plagued by weak experimental design poor randomization procedures insufficient sample size arbitrary deletion of apparent outliers and overly simplistic sta ...

DESCRIPTION provided by applicant The objective of this application is to develop an accurate high throughput genotoxicity screening system with high specificity and accuracy using our established and well validated toxicogenomic biomarker in cultured human cells Genotoxicity represented by chromosome damage and mutations in DNA is considered to be the hallmark of carcinogenic risk The standa ...