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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Treatment of Inflammatory Complications of Respiratory Infection

    SBC: Respana Therapeutics, Inc            Topic: NIAID

    Abstract Respana Therapeutics is advancing a proprietary first-in-class therapeutic monoclonal antibody (mAb), RT- 002, for the treatment of debilitating and often lethal inflammatory complications associated with acute respiratory conditions. We have identified a lead candidate, RT-002, and an equally promising alternative. RT-002 targets the surfactant protein A receptor SP-R210, a host-mediated ...

    STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Real-time Multimodal Diffuse Reflectance and Polarization Imaging Based Nerve Identification in Surgical Field of View

    SBC: YAYA SCIENTIFIC LLC            Topic: NIBIB

    PROJECT SUMMARY We propose to develop a novel non-contact, label-free multimodality imager that provides real-time intraoperative identification of nerves within the surgical field-of-view to facilitate the prevention of unintended nerve damage (termed iatrogenic nerve injury) during surgical procedures, as they are a major source of postsurgical complications, e.g., chronic pain. In the United St ...

    STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  3. SIRPant Technology for anti-Cancer Immunity

    SBC: SIRPANT IMMUNOTHERAPEUTICS INC            Topic: 102

    PROJECT SUMMARY Immune evasion is a hallmark of cancer. Various tumor immunotherapy treatments, such as immune checkpointblockade and cancer vaccination, have been developed to overcome cancer’s ability to avoid immune detectionand destruction; however, the result of these endeavors have not been satisfactory given a number of criticalbarriers. One of these barriers, and a prominent mechanism by ...

    STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Optimizing Radiosynthetic Yield of [18F]FTT For Wide-Spread Distribution

    SBC: Trevarx Biomedical, Inc.            Topic: 102

    ABSTRACT: Poly (ADP-ribose) polymerase inhibitors (PARPi’s) have emerged as important therapeutic agents targeting a broadening class of gene mutations approved for treatment of breast, ovarian, prostate, and other cancers. Genomic assays of BRCA-related genes and tumor homologous repair deficiency are used as companion diagnostics for PARPi therapy but have imperfect predictive efficacy for PAR ...

    STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Engineered Printed Propulsion Technology: A Study on Geometry-Based Thermal Management

    SBC: PLUS DESIGNS INC            Topic: MDA21T005

    Tungsten-based materials such as pure tungsten and tungsten-rhenium alloys are attractive hot-walled material options for solid rocket motor components, but they possess a high thermal diffusivity and can present some design challenges for thermal management. These challenges manifest themselves where geometric constraints, such as small thicknesses/volumes, coupled with long burn times and high t ...

    STTR Phase II 2023 Department of DefenseMissile Defense Agency
  6. A novel PEDF peptide mimetic for diabetic retinopathy

    SBC: SKYRAN BIOLOGICS, INC.            Topic: NEI

    Abstract The overall goal of Skyran Biologics is to develop a potent topical therapeutic for diabetic retinopathy (DR), a leading cause of vision loss globally. Our research team identified Pigment Epithelium-Derived Factor (PEDF) and showed it is expressed in the eye and provides significant protection to the injured retina. Since its discovery, we identified a 44-mer N-terminus bioactive region ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  7. Optimizing a Stapled-Peptide That Specifically Targets HSV-1 to Treat Herpes Ocular Keratitis

    SBC: FOX CHASE CHEMICAL DIVERSITY CENTER INC.            Topic: NIAID

    ABSTRACT Infection of the eye by Herpes Simplex Virus-1 (HSV-1) can result in Herpes Keratitis (HK), which is the leading cause of infectious corneal blindness worldwide. In the U.S., nearly 500,000 individuals experience ocular herpes infections that are often recurrent and culminate in progressive corneal scarring and loss of vision. The gold standard treatment is Acyclovir (ACV) that targets HS ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Rehabilitation Using Community-Based Affordable Robotic Exercise Systems (Rehab CARES)

    SBC: Recupero Robotics LLC            Topic: NICHD

    PROJECT SUMMARY Stroke is the leading cause of serious long-term disability. It is estimated that 5.8–6.5 million people currently live with stroke related disability in the US and that this number will increase by 20.5% by 2030. The current US health infrastructure is not prepared for these increasing numbers. Limitations in health insurance coverage and the shortage of rehabilitation practitio ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  9. Design and Fabrication of Novel Radiation Immune Vacuum Microelectronic Devices and Circuits

    SBC: INTERNATIONAL FEMTOSCIENCE, INCORPORATED            Topic: MDA20T004

    The DoD has identified a need to develop radiation hardened electronic components capable of surviving and operating through exposure to radiation environments encountered in space. To protect these electronic components, systems typically employ a combination of methods for radiation protection. International FemtoScience (FemtoSci) proposes a practical solution to produce Inherently Radiation Ha ...

    STTR Phase II 2022 Department of DefenseMissile Defense Agency
  10. High Strain-Rate Characterization Methods for Carbon-Carbon Composites at Elevated Temperature

    SBC: MATERIALS RESEARCH & DESIGN INC            Topic: MDA19T002

    Thermal Protection Systems (TPS) exhibit a damage mechanism known as “shear-plugging” when impacted by a hypervelocity projectile. Test methods to extract strain-rate dependent strength data relevant to shear-plugging of composite materials do not exist. Therefore, Materials Research & Design, Inc. (MR&D) and Southwest Research Institute (SwRI) propose to develop innovative test methods for th ...

    STTR Phase II 2021 Department of DefenseMissile Defense Agency
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