Award Data

THE REMEDIATION OF CONTAMINATED SOILS AND GROUNDS TO ENSURE PROTECTION OF PUBLIC HEALTH AND THE ENVIRONMENT IS DIFFICULTAND COSTLY. THERE IS A CRITICAL NEED FOR THE DEVELOPMENT OFTECHNOLOGIES WHICH ARE BOTH TECHNICALLY SOUND AND COST- EFFECTIVE. THE POTENTIAL REMOVAL OF ROGANIC CHEMICALS FROM UNSATURATED SOILS VIA VAPOR PHASE TRANSPORT APPEARS TO SHOW GREAT PROMISE. THIS APPROACH HAS APPLICABILITY ...

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DESCRIPTION (provided by applicant): MDI 301 is a synthetic retinoid that is similar to all-trans retinoic acid (RA) in its ability to stimulate collagen synthesis and inhibit the major collagen-degrading enzymes in skin. A major feature that distinguishes MDI 301 from RA is its lack of irritation when applied topically to skin. Recent studies from our laboratory have shown that topical treatment ...

DESCRIPTION (provided by applicant): MDI 301 is a synthetic retinoid that is similar to all-trans retinoic acid (RA) in its ability to stimulate collagen synthesis and inhibit the major collagen-degrading enzymes in skin. A feature that distinguishes MDI 301 from RA is its lack of irritation when applied topically to skin. Past studies from our laboratory have shown that topical pretreatment of ...

DESCRIPTION (provided by applicant): Wheelchair Drive System Over half of the wheelchair user population has developed upper extremity (UE) pain and injury. One of the activities that likely contribute to the development of injury is wheelchair propulsion. A number of technologies have been developed to address this issue including ergonomic pushrims, geared hub wheels, lever drives and pushrim-a ...

DESCRIPTION (provided by applicant): The proposed Universal Fingerprinting Chips (UFCs) are microarrays of thousands of oligonucleotide probes designed to interrogate the "sequence space" occupied by essentially any genome or transcriptome. The probe sequences are selected according to specific criteria tailored to the particular application. For example, the probe length will depend on the geneti ...

DESCRIPTION (provided by applicant): The aim of the proposed research is to develop an enabling technology that will allow development of a molecular diagnostic for identification and discrimination among closely related bacterial species that cause signif icant disease at low microorganism numbers. The technology will be advanced through the development of a diagnostic system for detection of spe ...

DESCRIPTION (provided by applicant): The goal of this Phase I SBIR project is to demonstrate the feasibility of a high-resolution truly three-dimensional (3D) color display for use in Medical data display applications. Such a display would tremendously improve remote (telepresence) medical teaching, diagnosis, and viewing of three-dimensional kinds of medical data (CT scans, MRI scans, PET scan ...

DESCRIPTION (provided by applicant): The goal of this Phase II SBIR project is to develop and build an Engineering Demonstration version of a unique and innovative truly three-dimensional (3D) display for use with 3D Medical data and in Medical Telepresenc e applications. There are presently many pseudo-3D displays - generally stereoscopic/two-view, or projection of one plane at a time on to a vol ...

DESCRIPTION (provided by applicant): One of the modern strategies for treating autoimmune diseases such as rheumatoid arthritis and psoriasis involves the use of biologic TNF receptor decoys, such as soluble receptors or therapeutic antibodies, to intercept the inflammatory ligand TNF-1, and thus block the pathological activation of its receptors. However, current TNF-1 biologic blockers are all d ...