Award Data

DESCRIPTION (provided by applicant): The long term aim of this project is to develop a novel wireless cardiac pacemaker electrode system. With the proposed technology, multiple such electrodes can be positioned at optimal sites within the coronary veins of the heart for cardiac resynchronization therapy, but require no lead wires from the pacing power source and controller. The wireless feature ...

DESCRIPTION (provided by applicant): Web-Based Wellness Policy Toolkit for Obesity Prevention in Middle Schools The childhood obesity epidemic is escalating with significant adverse health and economic impact. We propose to develop and test a web-based too lkit designed to facilitate implementation of required wellness policies (WP) in middle schools as well as a commercialization strategy for und ...

DESCRIPTION (provided by applicant): Sharing magnetic resonance imaging (MRI) brain scan results among colleagues is often difficult, because the data sets involve large numbers of digital images and require specialized software for effective analysis and visualization. Detailed analysis of anatomical MRI scans, for example, (each containing hundreds of images) benefits by using sophisticated s ...

DESCRIPTION (provided by applicant): Freezing of Gait (FOG) effects the majority of the approximately one million individuals who have Parkinson's disease nationwide and causes a cessation of movement that patients describe as feeling as if their feet are glued to the ground . FOG most often occurs in the mature stages of Parkinson's disease and results in a loss of balance and severe falls. Thes ...

DESCRIPTION (provided by applicant): The human inflammatory bowel diseases (IBDs), Crohn's disease (CD) and ulcerative colitis (UC), affect over one million Americans. Until recently, therapies for these disorders have non-specifically suppressed the immune response to inhibit intestinal inflammation. Specific understanding of immune pathways has led to the development of TNF blockade as a treatme ...

DESCRIPTION (provided by applicant): The human inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, affect over one million Americans and significant unmet medical needs still exist. Activation of NF??B transcription factors are central events in the initiation and perpetuation of chronic inflammation in IBD. TheraLogics, Inc., have been at the forefront of NF??B researc ...

DESCRIPTION (provided by applicant): Psoriasis is a common immune-mediated disease that affects approximately 2% of the US and European populations and significantly impacts the quality of life. T cells are recognized as primary mediators of the disease and new generation therapies aimed at eliminating reactive T cells or interfering with the immunologic cascade caused by their activation have bee ...

Abstract One in five Americans has chronic pain. Many pharmacological pain interventions exist but increase risk of opioid use disorder (OUD). As a result, there is an urgent need for non-addictive pain treatments. One non- addictive pain treatments is neurofeedback, or electroencephalogram (EEG) biofeedback, which trains patients to regulate brain states linked to physiological relaxation. Neurof ...

DESCRIPTION (provided by applicant): It is currently estimated that 15% of the world's population is undernourished and 5 million childhood deaths a year are attributable to malnutrition. The ability to feed the world in the future will be even more difficult due to population growth, climate change, water scarcity, and competition for land. It is widely recognized that advances in agricultu ...

Abstract Low back pain affects millions of Americans and causes $100 billion socioeconomic loss annually. One of the prominent risk factors is intervertebral disc degeneration. Current treatments are palliative for relieving pain without restoring disc biology or biomechanics. Pain recurrence is common. Spinal fusion is popular, but it is limited by high failure rate (up to 30%) while predisposes ...