Award Data

Abstract We propose to initiate preclinical development of a gene therapeutic targeted to Alzheimer's Disease. The World Health Organization's and Alzheimer's Disease International's report on Dementia (2012) recognizes that the global burden of AlzheimerDisease is forecast to worsen significantly with prevalence predicted to double every 20 years. Interventions that could prov ...

Project Summary Abstract Synthetic arteriovenous grafts AVGs can provide life sustaining vascular access for dialysis patients but are subject to multiple modes of failure and complications related to chronic needle cannulation poor graft identification delayed access and bleeding These graft needle cannulation associated complications translate to millions of dollars in health care expense ...

Obscurant technologies continue to be of high value to today’s Warfighter, what has evolved from smoke released from a canister are now high precision manufactured structures designed for individual targeted use cases. While the technology to model, design, and manufacture these items has increased, testing methodologies and apparatus have largely been restricted to large scale events. What is n ...

The development of a burn-in process for high power MWIR and LWIR Quantum Cascade Lasers (QCLs) is proposed. The new burn-in process will be rooted in extensive statistical experimental data to be collected in Phase I and Phase II of this program. This will allow us to extract all the critical empirical parameters required for mean-time-to-failure (MTTF) projections for high power MWIR and LWIR de ...

Research in Flight and Utah State University are proposing the development of an accelerated preconditioner for high-fidelity numerical simulations of hypersonic air vehicles in early design stages. This capability will assist hypersonic aircraft OEM to o

PROJECT SUMMARY The proposed Phase I STTR project is a partnership between a biotechnology company KXTbioIncand the University of North Carolina at Chapel Hill to develop an innovative high throughput screening service for identifying new drug candidates that act via G protein coupled receptorsGPCRsThis large protein superfamily has been the most successful source of therapeutic targetsaccounting ...

This Phase I proposal will utilize multivariate regression, including cluster and principal component analysis to categorize lots of HTPB R-45M based on their physicochemical properties. Artificial intelligence-driven pattern recognition analysis will be performed on a variety of HTPB characterization data and spectra. Categorized data will be assessed against measured outcomes (pot life, mechanic ...

Over 30% of age-eligible Americans fail to receive recommended screening for colorectal cancer (CRC), the second leading cause of cancer death in the United States. Multilevel barriers explain why so many Americans fail to receive routine CRC screening. Patients report a lack of knowledge about the need for screening or their screening options, and many view screening as messy, uncomfortable, or e ...

DESCRIPTION (provided by applicant): Propionibacterium acnes (P. acnes) is most notably recognized for its role in acne vulgaris, the most common skin disease, affecting 85-100% of the population at some point in their lives. Current treatments for vulgari s acne using isotretinoin (13-cis-retinoic acid) or antibiotics can have many undesirable effects, including depression, teratogenicity, hormon ...

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