Award Data

DESCRIPTION (provided by applicant): Reliable diagnostic differentiation between acute and chronic myocardial infarcts would be of great benefit for cardiac surgeons and interventional cardiologists. Such differentiation could be used to make decisions about which vessels and in what order would be reopened or bypassed. MRI is an intrinsically noninvasive diagnostic tool and the Delayed Enhancemen ...

We propose the development of advanced encryption techniques to make integrated circuits more secure against unauthorized intrusion, specifically the use of innovative embedded techniques to make reprogramming of high performance deep sub-micron or nano-scale FPGA or custom ASIC systems by other than the intended recipient essentially impossible. The specific concerns addressed in this proposal r ...

This effort proposes to design and demonstrate the concept of an innovative, Advanced BMDS Multisensor Fused Track and Discrimination Architecture that will enhance the generation of a Single Integrated Picture of the Battlespace. This Architecture permits enhancement of sensor-to-sensor track correlation handover of objects while characterizing their lethality for later target designation purpos ...

ABSTRACT: Missile defense radars use wideband waveforms along with coherent processing to extract detailed target features and perform high range /Doppler resolution functions. Reduced RCS targets embedded in high clutter (chaff, or chaff-like fuel debris, etc.) environments present significant challenges. Closely spaced objects and decoys accompanying targets of interest inherently increase the c ...

DESCRIPTION (provided by applicant): The convergence of biomedicine and computation in the form of biomedical computing has demonstrated gains in the areas of genetic sequences, biomedical images, qualitative descriptors for health and social science and geospatial images and chemical formulae. This provides a unique opportunity to utilize novel image processing techniques to more accurately and o ...

In this program, we will combine commercially available AlGaN/GaN on Si FETs with short gates such that the high frequency performance (X-band and higher) can be significantly increased. The AlGaN/GaN material system has significant advantages over the incumbent technology for X-band applications; specifically, AlGaN/GaN FETs have much higher power density which translates into broader bandwidth. ...

DESCRIPTION (provided by applicant): Molecular interactions form the foundation of biology and chemistry. They are central to life itself and determine catalytic activity, cellular function, and therapeutic efficacy. The vast majority of diagnostic procedures depend on some type of specific molecular interaction. Therefore, the ability to perform pure liquid-phase molecular binding analysis at hi ...

DESCRIPTION (provided by applicant): In the course of previous basic studies in our laboratory, we have developed statistically significant and robust Quantitative Structure-Activity Relationships (QSAR) methodologies, which incorporate rigorous validation procedures and lead to models with a high predictive power and practical utility. The methodologies are built upon the similarity principle, i. ...

DESCRIPTION (provided by applicant): Allogeneic stem cell transplantation (allo-SCT) is potentially curative therapy for a patients suffering from leukemia, lymphoma and multiple myeloma. However, the problems associated with graft-versus-host disease (GVHD) have greatly limited the use of allo-SCT to patients with either an HLA-identical family member or unrelated donor in many transplant centers ...

DESCRIPTION (provided by applicant): A number of characteristics of the Adenovirus type 5 (Ad5) make it an optimal gene therapy/virotherapy vector suitable for a wide array of cancer therapeutic approaches. Despite these advantages, overall ifficacy remains limited by sub-optimal adenovirus delivery to cancer tissues. One conceptual approach to overcome this limitation is to achieve an amplificati ...