Award Data

DESCRIPTION provided by applicant We devised a new generation highly sensitivity method to diagnosis peripheral neuropathy early when the probability for reversal is greatest Cancer chemotherapy and diabetes are the most common causes of neuropathy in the USA Both cause decreased sweating abnormal circulation peripheral numbness pain and weakness If diagnosed early both are potentially ...

DESCRIPTION (provided by applicant): Anthrax is an infectious illness that has been known for many years, largely in rural settings, but since the terrorist attacks of 9-11, has recently emerged as a major national security concern. Bacillus anthracis, the causative agent of anthrax, exists naturally in various forms and is now considered a bioterrorism agent. There is fear that this microbe coul ...

DESCRIPTION (provided by applicant): Molecular interactions form the foundation of biology and chemistry. They are central to life itself and determine catalytic activity, cellular function, and therapeutic efficacy. The vast majority of diagnostic procedures depend on some type of specific molecular interaction. Therefore, the ability to perform pure liquid-phase molecular binding analysis at hi ...

DESCRIPTION (provided by applicant): Atherosclerosis is the underlying cause of most cardiovascular disease and considerable evidence supports the role of hypercholesterolemia as a risk factor for this disease. In preliminary work, we found that tertiary-butyl hydroquinone (TBHQ), at a dose lower than approved for human use, was effective in reducing plasma levels of both total cholesterol and tri ...

DESCRIPTION (provided by applicant): The ultimate goal of this project is treatment of beta-thalassemia, a genetic blood disease, with antisense oligonucleotides. The project is based on the technology developed by the PI in which antisense oligonucleotides are used to restore correct functioning of a defective gene rather than, as commonly practiced, to inhibit the expression of an undesirable ge ...

DESCRIPTION (provided by applicant): Stroke is the leading cause of adult disability and the third leading cause of death in the United States. Approximately 15 million people in the world, and more than 700,000 people in the United States, experience a stroke each year. Following a hemispheric stroke, motor control of extremities on one side of the body is usually affected. Many patients suffer a ...

The objective of this proposal is to demonstrate the novel type of mode selection for high power lasers for target tracking and interception. In Phase I, LPTI proved the concept of volume Bragg gratings (VBGs), which were recorded in photo-thermo-refractive (PTR) glass, as effective selectors of transverse modes for pulsed neodymium laser. Dramatic narrowing of angular divergence of Nd:YAG laser w ...

The objective of this proposal is to demonstrate the novel type of mode selection for high power lasers for target tracking and interception. In Phase I, LPTI proved the concept of volume Bragg gratings (VBGs), which were recorded in photo-thermo-refractive (PTR) glass, as effective selectors of transverse modes for pulsed neodymium laser. Dramatic narrowing of angular divergence of Nd:YAG laser w ...

DESCRIPTION (provided by applicant): The purpose of this Phase II STTR is to complete the development of a web-based training system, the All Stars Online Community. This system is designed to improve teachers' delivery of All Stars, an adolescent substance use prevention program. The goal of training is to help teachers advance in their teaching skills and understanding of underlying preventi ...

DESCRIPTION (provided by applicant): The purpose of this Phase II STTR is to complete the development of a web-based training system, the All Stars Online Community. This system is designed to improve teachers' delivery of All Stars, an adolescent substance use prevention program. The goal of training is to help teachers advance in their teaching skills and understanding of underlying preventi ...