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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Alkoxylamine nucleosides for sequencing by synthesis

    SBC: Genomechanix, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): This Phase I STTR proposal seeks funding to transfer technology from the Foundation for Applied Molecular Evolution (nonprofit) to GenoMechanix (for-profit) relating to a strategy for doing "sequencing by synthesis". This strategy involves the incorporation, in a template-directed polymerization step, of a nucleoside triphosphate having its 3'-hydroxyl group ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  2. An Advanced Biosensor for Molecular Interaction Studies.

    SBC: MOLECULAR SENSING, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Molecular interactions form the foundation of biology and chemistry. They are central to life itself and determine catalytic activity, cellular function, and therapeutic efficacy. The vast majority of diagnostic procedures depend on some type of specific molecular interaction. Therefore, the ability to perform pure liquid-phase molecular binding analysis at hi ...

    STTR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  3. A Novel Protection Device for Shock Wave Lithotripter

    SBC: Genognomon, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The shock wave lithotripsy (SWL) was first introduced successfully in clinical treatment in the earlier 1980s by Dornier Medical System in Germany. Now it has become the modality for urolithiasis diseases. However, SWL also causes acute renal injury, such as hemorrhage, hematoma, edema and enlargement of kidney. Although most patients recover well following ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  4. Antimicrobial-releasing gels for preventing infection in total joint arthroplasty

    SBC: SONORAN BIOSCIENCES INC            Topic: NIAMS

    DESCRIPTION (provided by applicant): Orthopaedic Surgical Site Infections (SSIs), including Prosthetic Joint Infections (PJIs), are an extremely costly health care problem, illustrated by the 70,000- 114,000 average total cost per case to treat more than20,000 hip and knee replacement infections in the US each year. When a prosthetic joint becomes infected following arthroplasty, organisms form ...

    STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  5. Antisense Treatment for Thalassemia. Preclinical study.

    SBC: ERCOLE BIOTECH, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The ultimate goal of this project is treatment of beta-thalassemia, a genetic blood disease, with antisense oligonucleotides. The project is based on the technology developed by the PI in which antisense oligonucleotides are used to restore correct functioning of a defective gene rather than, as commonly practiced, to inhibit the expression of an undesirable ge ...

    STTR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  6. A Worldwide Research Network of Dynamic Cardiac Images

    SBC: HEART IMAGING TECHNOLOGIES, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): This is a Phase I of a fast-track STTR application submitted in response to Program Announcement PA-03-001 ("Knowledge Integration across Distributed Heterogeneous Data Sources"). We propose a collaborative effort between Heart Imaging Technologies, LLC (HeartIT) and Duke University's Cardiovascular Magnetic Resonance Center (DCMRC). The goal of the collaborati ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  7. Bioreactor for Engineered Bioartificial Tissues (BATS)

    SBC: Flexcell International Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Few commercial bioreactors are available for the culture of three dimensional (3D) tissues. Flexcell's strategy is to provide a commercial bioreactor allowing ease of operation to produce molded 3D tissue constructs in cell- populated matrix gels of variable geometries with controlled nutrient perfusion and mechanical stimulation. This design is based on a vali ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  8. Commercialization of a Diagnostic test for amyotrophic lateral sclerosis (ALS)

    SBC: IRON HORSE DIAGNOSTICS, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): Amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) is a fatal neurodegenerative disease with a typical lifespan of 3 - 5 years after diagnosis. The initial symptoms can be similar to many other neurologic disorders and often begin with limb weakness, muscle fasciculations, or increasing difficulties in speech or breathing. No definitive diagnostic ...

    STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  9. Controlling mechanical signal transduction to treat osteoarthritis

    SBC: Cytex Therapeutics, Inc.            Topic: NIA

    DESCRIPTION (provided by applicant): Controlling mechanical signal transduction to treat osteoarthritis Abstract The TRPV4 calcium (Ca++) permeable ion channel has been shown to be expressed and functional in chondrocytes, the cells responsible for the maintenance of cartilage in weight-bearing joints. Trauma of joints with subsequent damage of cartilage, as well as chronically increased joint loa ...

    STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  10. Cord Blood: Treatment for Acute Myocardial Infarction

    SBC: SANERON CCEL THERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Transplantation of human umbilical cord stem cells (hUCBC) has been shown to be effective in limiting infarct size and in the preservation of left ventricular function and anatomy in a rat model. These effects have been present in studies both utilizing and not utilizing immunosuppression. Whether immunosuppression will be required in a large animal model is un ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
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