Award Data

Project Summary Abstract Synthetic arteriovenous grafts AVGs can provide life sustaining vascular access for dialysis patients but are subject to multiple modes of failure and complications related to chronic needle cannulation poor graft identification delayed access and bleeding These graft needle cannulation associated complications translate to millions of dollars in health care expense ...

Additive Manufacturing (AM) has a potential to significantly reduce the cost and lead time associated with the maintenance and sustainment issues faced by the US Navy. However, current materials such as 17-4 PH Stainless Steel typically achieve half the required mechanical properties when additively manufactured, thus limiting the use of AM in critical parts. Recent advancements in carbon nanotube ...

With Project AEQUOR-V Aurora, in partnership with Purdue University, proposes to complete the conceptual design of a hybrid unmanned air/underwater vehicle (HUA/UV) capable of transitioning repeatedly between aerial and underwater operations in a single mission, operating in water depths up to 40 ft, and carrying a significant payload. To accomplish this goal, Aurora will build on design experienc ...

DESCRIPTION (provided by applicant): Molecular interactions form the foundation of biology and chemistry. They are central to life itself and determine catalytic activity, cellular function, and therapeutic efficacy. The vast majority of diagnostic procedures depend on some type of specific molecular interaction. Therefore, the ability to perform pure liquid-phase molecular binding analysis at hi ...

Innovative Veterinary Medicine, Inc. has conceptualized and designed an anesthesia ventilator named DolVent™ specifically for the Navy Atlantic bottlenose dolphins and California sea lions. The DolVent™ ventilator design will support the normal physiologic state of these animals using ventilation modes mimicking their natural breathing including the modes of Airway Pressure Release Ventilation ...

PROJECT SUMMARY Nucleosomes are the basic building blocks of chromatin and composed of bp DNA wrapped around a core histone octamer Chromatin function is controlled by the dynamic addition removal of histone post translational modifications PTMs Significantly alterations in specific PTMs are associated with changes in gene expression driving the emergence progression of many cancer ...

Project Summary Abstract The goal of this proposal is to develop a novel high throughput platform for understanding gene regulatory elements in order to identify new drug targets for common diseases The human genome encodes approximately genes Understanding how those genes are regulated and how this correlates to complex cell phenotypes has long been a major focus of our team Follow up p ...

DESCRIPTION (provided by applicant): The objective of this proposal is to exploit a newly discovered anti-inflammatory function involving the aminopeptidase activity of the leukotriene A4 hydrolase for the treatment of pulmonary emphysema. The leukotrieneA4 hydrolase is a dual-functioning enzyme with dichotomously opposing functions. As an epoxide hydrolase, it catalyzes the conversion of leukotri ...

DESCRIPTION provided by applicant Problem Lower gastrointestinal bleeding is a significant medical problem in the United States accounting for more than hospital admissions and tens of billions of dollars of healthcare spending annually It is common for bleeding from a single site to stop and restart multiple times The three modalities now used to diagnose and locate gastrointestina ...

Project Summary/Abstract Ocular pharmaceuticals predominantly use the topical route of administration, which involves a number of benefits and limitations when compared to systemic drug routes. A major limitation of the ocular topical route is the rapid loss of drug via tearing and nasolacrimal drainage, requiring the use of frequent dosing and high drug concentrations that then create formulation ...