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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Real-time Multimodal Diffuse Reflectance and Polarization Imaging Based Nerve Identification in Surgical Field of View

    SBC: YAYA SCIENTIFIC LLC            Topic: NIBIB

    PROJECT SUMMARY We propose to develop a novel non-contact, label-free multimodality imager that provides real-time intraoperative identification of nerves within the surgical field-of-view to facilitate the prevention of unintended nerve damage (termed iatrogenic nerve injury) during surgical procedures, as they are a major source of postsurgical complications, e.g., chronic pain. In the United St ...

    STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Optimizing Small Molecule Mechanomimetics to Treat Age-related Osteoporosis.

    SBC: OAK RIDGE THERAPEUTIC DISCOVERY LLC            Topic: NIA

    Abstract There is an unmet need to develop treatments for senile osteoporosis, a disorder characterized by an age-related reciprocal decrease in osteogenesis and increase in bone marrow fat. Senile osteoporosis resembles disuse osteopenia, suggesting its pathogenesis involves impaired bone mechanosensing. We discovered that the polycystin heterotrimeric complex (1PC1+3PC2) functions as a mechanose ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Developing a selective TRPC3 ion channel inhibitor for epilepsy treatment

    SBC: SEAK Therapeutics, LLC            Topic: 106

    Project SummaryEpilepsy is one of the most common brain disorders. Current drugs have limited efficacy. Identifying new targeted drugs that can be used as safer, more effective therapies is in urgent unmet need. Selective inhibition of the transient receptor potential canonical 3 (TRPC3) emerges as a novel strategy to impede epilepsy. However, the currently best selective TRPC3 inhibitor, Pyr3, ha ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Cell permeant peptidomimetics to prevent delayed vasospasm and neurological deficits after subarachnoid hemorrhage

    SBC: VasaMetrix            Topic: 107

    PROJECT SUMMARYSubarachnoid hemorrhage (SAH) due to rupture of an intracranial aneurysm leads to delayed vasospasm resulting in neuroischemia (stroke). The overall morbidity (profound neurologic deficit in 10-20% of survivors) and mortality (50%) are high, and the disease affects a relatively young adult population. Therapeutic options to prevent delayed vasospasm and neuroischemia after SAH are c ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. Real-Time Quantitation of Transport Across Vascular-Tissue Interfaces in Organ-On-Chip Models Using In Situ Mass Spectrometry

    SBC: CFD RESEARCH CORPORATION            Topic: 400

    Abstract Current in vitro platforms are poor predictors of the in vivo safety, efficacy and pharmacokinetics of therapeutics, owing to a significant difference in the test conditions compared to physiological conditions. Therefore, drug toxicity testing is routinely performed using animal models. However, animal testing is expensive and time consuming. In addition, ethical concerns about the use o ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Label-free, Multimodality Diffuse Reflectance and Polarization-Based Proximity Probe for Iatrogenic Nerve Injury Prevention During Surgical Procedures

    SBC: YAYA SCIENTIFIC LLC            Topic: NIBIB

    PROJECT SUMMARY We propose to develop a novel contact, label-free multimodality-based sensing probe that provides real-time intraoperative identification of nerves within the thermal damage threshold range of a surgical tool. The tool will facilitate prevention of direct/indirect nerve damage (termed iatrogenic nerve injury) during surgical procedures, as they are a major source of postsurgical co ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  7. Algorithm to Identify Patients at Risk of Medication-Related Hospitalization

    SBC: L. KRENK, INC.            Topic: R

    The long-range goal of this fast-track research application is to improve healthcare quality and reduce healthcare costs nationwide among those at risk for medication-related hospitalization. The specific objective of this proposed research is to develop an algorithm that uses existing electronic health information to efficiently identify patients at risk of medication-related hospitalization so t ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Assessment of a Microprocessor Ankle for Low Mobility Individuals with Amputation

    SBC: Synchro Motion LLC            Topic: NICHD

    PROJECT SUMMARYMicroprocessor-controlled ankles have been shown to substantially improve mobility and stability in individuals with lower limb amputation, but these devices are typically only available to higher mobility users due to a lack of scientific evidence to justify insurance reimbursement. As such, many of the individuals with lower limb amputation that have the greatest need for advanced ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a molecular-level skin condition diagnostic for precision medicine

    SBC: Finally, LLC            Topic: NIAMS

    PROJECT SUMMARY The American Academy of Dermatology reports that 1 in 4 Americans (~84.5 million) are impacted by skin disease. Skin disease is the fourth leading cause of disability worldwide, significantly impacts quality of life, and costs ~$75 billion annually to treat. Skin conditions like atopic dermatitis (AD) are commonly diagnosed by practitioners using clinical history and physical exam ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  10. Latinos Kick Buts: Mobile Engagement and Cessation Support for Latino Smokers Phase II

    SBC: AGILE HEALTH INC            Topic: 102

    PROJECT SUMMARY Despite a growing need for smoking cessation services, Latino smokers face notable disparities in cessation treatment. Consequently, there is a big opportunity, both from a scientific and a business perspective, to develop and test the most optimal culturally tailored approaches to enroll and engage Latino Smokers into cessation programs. The Kick Buts program owned by Agile Health ...

    STTR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
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