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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. A simple and effective diagnostic test for gastrointestinal bleeding to improve patient outcomes

    SBC: CUMBERLAND PHARMACEUTICALS INC.            Topic: 300

    DESCRIPTION provided by applicant Problem Lower gastrointestinal bleeding is a significant medical problem in the United States accounting for more than hospital admissions and tens of billions of dollars of healthcare spending annually It is common for bleeding from a single site to stop and restart multiple times The three modalities now used to diagnose and locate gastrointestina ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Automated Object Contouring Methods & Software for Thoracic Radiotherapy Planning

    SBC: Quantitative Radiology Solutions LLC            Topic: 102

    DESCRIPTION provided by applicant In nearly million new cancer cases are estimated to occur in the US where nearly two thirds will have treatment by radiation therapy In current clinical practice organ contour delineation on medical images is still performed with low levels of automation due to lack of highly automated commercial contouring software This deteriorates therapy plann ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Biological super-resolution imaging using high-index microspheres for cancer research application

    SBC: SphereVis LLC            Topic: 400

    DESCRIPTION provided by applicant Optical microscopy is the most commonly used imaging technique in life and material sciences however the spatial resolution of any standard microscope is fundamentally limited by the diffraction of light waves which for visible light restricts spatial resolution to nm Surpassing the diffraction limit significantly impacts several disciplines such as me ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Development of novel research tools and a database for mapping human mitochondrial tRNA modifications by mass spectrometry

    SBC: Ribonova Inc.            Topic: R42

    Summary In this fast track Phase I II STTR project a novel mass spectrometry method and a matched reagent kit will be developed for mapping modified nucleotides in human mitochondrial transfer RNA mt tRNA including the most abundant modification pseudouridine which hitherto has proved to be a technical challenge because it is an isomer of uridine These new research tools will be harnessed to build ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Highly specific ATR inhibitors for the targeted treatment of a broad spectrum of cancers

    SBC: Atrin Pharmaceuticals            Topic: 103

    PROJECT SUMMARY Specific targeting of the Ataxia Telangiectasia and Rad related kinase ATR represents an emerging strategy to treat a broad spectrum of cancers most notably those that currently lack effective treatments Suppression of ATR selectively kills cells subjected to oncogenic stress alternative lengthening of telomeres ALT or loss of double strand break DSB repair mechanisms A ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Infectious Disease Diagnostics and Differentiation of Viral vs. Bacterial Infections for Point of Care Applications

    SBC: GENECAPTURE            Topic: CBD15C001

    The modern warfighter faces the constant threat of endemic infections, multi-drug resistant bacteria and Biological Warfare Agents. In order to provide accurate front-line treatment that will curtail the overuse of antibiotics, a rapid and robust molecula

    STTR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  7. Innovative Mitigation of Radiation Effects in Advanced Technology Nodes

    SBC: Reliable MicroSystems, LLC            Topic: DTRA16A003

    Establish a radiation-aware analysis capability in a commercial EDA design flow that will enable first-pass success in radiation-hardened by design (RHBD) for DoD ASICs in much the same way that existing EDA design suites ensure first pass functionality and performance success of complex ASICs destined for commercial applications. Layout-aware, calibrated single-event radiation models that captur ...

    STTR Phase I 2016 Department of DefenseDefense Threat Reduction Agency
  8. Intervention to encourage HIV Testing and Counseling among Adolescents

    SBC: Schell Games LLC            Topic: NICHD

    DESCRIPTION provided by applicant HIV disproportionately impacts minority adolescents and most of them have neither undergone HIV testing and counseling HTC nor know their status Adolescence is a andquot window of opportunityandquot to intervene with HIV behavior change interventions Challenges to implementing and disseminating some effective HIV prevention programs in adolescents may lim ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. In vitro human model for individualized response to CFTR modulators

    SBC: Progenra, Inc            Topic: NHLBI

    DESCRIPTION provided by applicant The approval of the cystic fibrosis CF drug invocator for patients with the G D mutation validates CFTR modulators for improving clinical outcomes in CF For most CF patients with F del and other mutations however multi drug combination therapy will likely be necessary and sensitive biomarkers of augmented CFTR function in response to various agents ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Macromolecule Crystallization Screening Results Analysis

    SBC: iXpressGenes, Inc.            Topic: 100

    Project Summary Crystallization followed by subsequent structure determination is a major step in understanding the structure function relationship of macromolecules Understanding macromolecule structure has become a key part in the development of new pharmaceuticals and is a major area of NIH research Crystallization however is also the rate limiting step despite technological efforts to a ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
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