Award Data

Protein manufacturing is of paramount importance to chemical and biological defense applications. Existing protein purification methods primarily rely on synthetic-resin based chromatography, which is time-consuming, labor-intensive, expensive, and consequently, ill-suited for developing rapid countermeasures to chemical and biological threats. To overcome these limitations, the overall goal of th ...

DESCRIPTION provided by applicant Most clinical assays begin with blood collection in a laboratory setting The Gates foundation and many others have recognized and attempted to deal with the fact that in much of the world clinical testing is done in a primitive setting The luxury of having a phlebotomist to draw blood with a laboratory to prepare serum or plasma for analysis is not universal ...

Safe and efficient ionization and filtration technology compatible to biodefense applications is of paramount importance. Current ionization methods are energy-intensive, costly, prone to ozone generation, or inefficient, and consequently ill-suited for building protection applications. To overcome these limitations, we propose to develop and demonstrate a novel bioaerosol ionization and collectio ...

DESCRIPTION provided by applicant Biologics manufacturing based on cell culture techniques represents a tremendous advance in the pharmaceutical industry The use of biological rather than chemical processes result in unique therapeutics with greater profitability a knowledge based barrier to entry and the ability to develop therapeutics targeted at specific subsets of the population i e p ...

DESCRIPTION provided by applicant In recent years there has been increased interest throughout the world in the use of proton radiation therapy for treatment of cancer and independent studies project a annual increase in the installed base The replacement of X ray therapy with proton therapy will have substantial long term benefit to patients due to greatly reduced long and short term tox ...

Electronic waste (e-waste) is one of the most rapidly growing waste problems worldwide. Improper handling of e-waste results in vast amounts of toxic waste being sent to landfill and leaching into the water supply. Due to these concerns, e-waste recycling is a rapidly growing industry. Unfortunately, most current e-waste recycling processes rely on either manual hand sorting or differential densit ...

DESCRIPTION provided by applicant In the absence of effective approved drugs or vaccines vector control remains the only means of intervention for many against mosquito borne diseases This problem grows more complex with the recent establishment of multiple exotic mosquito species and mosquito borne pathogens Furthermore changing climate conditions are predicted to alter the traditional ra ...

DESCRIPTION provided by applicant This project aims to generate blood tests for mild cognitive impairment MCI and conversion risk from MCI to full blown Alzheimerandapos s disease AD We have reported that systemic footprints increases in key micro RNA miR levels are identifiable in AD blood samples here we suggest that this is also true for MCI the pre AD phase Our recent ...

DESCRIPTION (provided by applicant): PharmacoPhotonics (DBA FAST, Inc.) proposes Fast-Track research to determine GFR in its first human Pilot study. The long-term goal of this SBIR project is to test FAST's minimally invasive catheter based fluorescent device in humans and commercialize this device for rapid detection and quantification of glomerular filtration rate (GFR) in patients with ac ...

DESCRIPTION provided by applicant An important discovery and validation event occurred recently within human cell based drug discovery programs at DiscoveryBioMed Inc DBM yielding a lead class of cytostatic anti proliferative small molecules that display nanomolar potency and marked efficacy against hyperproliferative human PKD cells that create and line remodeled PKD cysts within emergen ...