Award Data

Advanced turbomachinery components play a critical role in launch vehicle and spacecraft liquid rocket propulsion systems. To achieve desired efficiencies, extremely tight tolerances are often imposed between inducer blades and shrouds or other system components which sets up strong interactions that influence both the aerodynamics and the structural performance of blades and vanes. These transien ...

Chemical contamination of spacecraft components as well as thermal and force loading from firing liquid propellant thrusters are critical concerns for in-space propulsion applications. Gas molecular contamination and liquid droplet deposition due to incomplete combustion threaten to damage surface materials, sensitive instruments and optical sensors, and poses major risks for mission success. Liqu ...

DESCRIPTION provided by applicant Therapeutics is focused on the development of adjuvant systems with desired immune activities for targeted indications The Companyandapos s immune stimulatory adjuvant platform builds on combinatorial use of immune agonists with distinct immune targets and mechanisms of action for the generation of therapeutic immune responses Critical to this platform techno ...

ABSTRACT Traditional approaches to drug development for Alzheimer s disease are becoming increasingly expensive and in many cases disappointingly unsuccessful Based on preliminary in vitro and in vivo studies we have identified a novel small molecule methyl dimethyl oxo dihydrobenzo c naphthyridine carboxylate UK that significantly decreases A production and pro in ...

DESCRIPTION provided by applicant Insulin resistance IR also known as metabolic syndrome is tied to obesity and is associated with numerous modern health problems including the growing problems of type diabetes and cardiovascular disease The growing health economic and social burdens of these conditions calls for the need to develop drug treatments for IR We know from multiple lines of ...

DESCRIPTION provided by applicant Problem Lower gastrointestinal bleeding is a significant medical problem in the United States accounting for more than hospital admissions and tens of billions of dollars of healthcare spending annually It is common for bleeding from a single site to stop and restart multiple times The three modalities now used to diagnose and locate gastrointestina ...

DESCRIPTION provided by applicant There is growing awareness that weakness of muscle is a significant biomedical health issue associated with many different chronic diseases and aging There are a variety of different diseases that affect muscle including muscular dystrophy fibromyalgia cerebral palsy amyotrophic lateral sclerosis and myasthenia gravis each of which carries its own uniqu ...

Project Summary Crystallization followed by subsequent structure determination is a major step in understanding the structure function relationship of macromolecules Understanding macromolecule structure has become a key part in the development of new pharmaceuticals and is a major area of NIH research Crystallization however is also the rate limiting step despite technological efforts to a ...

GTL?s SNS technology aids in the operation of new or existing structural health monitoring (SHM) systems by integrating data and power pathways into the structure. The use of this technology within a composite structure would allow engineers to place sensors from an SHM system directly where they are needed on a structure with instant power. GTL?s SNS technology offers the potential for developers ...

NASA recognizes the importance of conservation, smart utilization and reuse of resources for their deep space missions to address the need for regeneration of air, water and waste with highly reliable systems to reduce mission payload. Additionally, energy for life support and other systems needs to be obtained from renewable energy sources or waste streams. In order to address NASA's requirements ...