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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Target Identification for Novel Small Molecule Therapeutic for Alzheimer's disease

    SBC: CoPlex Therapeutics, LLC            Topic: NIA

    ABSTRACT Traditional approaches to drug development for Alzheimer s disease are becoming increasingly expensive and in many cases disappointingly unsuccessful Based on preliminary in vitro and in vivo studies we have identified a novel small molecule methyl dimethyl oxo dihydrobenzo c naphthyridine carboxylate UK that significantly decreases A production and pro in ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Topical application of heterologous protein-expressing Staphylococcus epidermidis for potential therapeutic treatment of skin diseases

    SBC: Azitra Inc.            Topic: NIAID

    PROJECT SUMMARY Current treatment options for a number of skin diseases generally aim for symptomatic relief and fail to address underlying pathophysiological changes leading to skin disease In the case of genetic mutations that cause loss of function mutations supplementation of the missing protein is a viable approach to treatment However delivery of functional protein to the target keratino ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Therapeutic inhibition of P. aeruginosa nitrogen respiration in chronic infection

    SBC: L2 DIAGNOSTICS LLC            Topic: NIAID

    DESCRIPTION provided by applicant The goal of this STTR is to identify novel small molecule compounds targeting the nitrogen respiration pathway of Pseudomonas aeruginosa This pathway is crucial to the pathogenesis of P aeruginosa in vivo but has not yet been exploited for antimicrobial drug discovery There is a clear need for new treatments to combat P aeruginosa infections Antibiotic re ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Macromolecule Crystallization Screening Results Analysis

    SBC: iXpressGenes, Inc.            Topic: 100

    Project Summary Crystallization followed by subsequent structure determination is a major step in understanding the structure function relationship of macromolecules Understanding macromolecule structure has become a key part in the development of new pharmaceuticals and is a major area of NIH research Crystallization however is also the rate limiting step despite technological efforts to a ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Fast and Flexible Differential Equation Model Fitting with Application to Pharmacometrics

    SBC: Metrum Research Group LLC            Topic: N16AT016

    Differential equations are widely used to analyze and simulate the dynamics of complex systems in the physical, biological and social sciences. Inferences with such models are challenging due to both statistical and computational complexity. Stan is a widely used, open-source, probabilistic programming language and Bayesian inference engine. We propose to extend Stan by incorporating solvers for o ...

    STTR Phase I 2016 Department of DefenseNavy
  6. Embedded Space Analytics

    SBC: INFOBEYOND TECHNOLOGY LLC            Topic: N16AT020

    Navy needs a real-time graph embedding tool for analyzing huge graphs (millions of nodes and billions of edges) from diverse sources. However, current approaches cannot provide dynamic and scalable graph analytics to show the military value of tactical data. In this project, InfoBeyond advocates EStreaming (Embedding & Streaming) for scalable and efficient graph streaming. EStreaming promotes big ...

    STTR Phase I 2016 Department of DefenseNavy
  7. High Performance Energetic Propellant Ingredient Process Research and Development

    SBC: NALAS ENGINEERING SERVICES INC            Topic: N16AT021

    Current state of the art oxidizers have been in service for decades, leaving the performance of our munitions and propulsion systems unchanged while our tactical objectives have increased in their requirements. Keeping with ongoing changes in the worlds military, maintaining a tactical advantage while meeting or exceeding mission capability requirements is of utmost importance for our nation. As s ...

    STTR Phase I 2016 Department of DefenseNavy
  8. High Performance Energetic Propellant Ingredient Process Research and Development

    SBC: NALAS ENGINEERING SERVICES INC            Topic: N16AT021

    Current state of the art oxidizers have been in service for decades, leaving the performance of our munitions and propulsion systems unchanged while our tactical objectives have increased in their requirements. Keeping with ongoing changes in the worlds military, maintaining a tactical advantage while meeting or exceeding mission capability requirements is of utmost importance for our nation. As s ...

    STTR Phase I 2016 Department of DefenseNavy
  9. Developing a novel adjuvant system for therapeutic vaccines against lung cancer

    SBC: FasCure Therapeutics LLC            Topic: 102

    DESCRIPTION provided by applicant Therapeutics is focused on the development of adjuvant systems with desired immune activities for targeted indications The Companyandapos s immune stimulatory adjuvant platform builds on combinatorial use of immune agonists with distinct immune targets and mechanisms of action for the generation of therapeutic immune responses Critical to this platform techno ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. A Method to Increase Buprenorphine Treatment Capacity and Effectiveness

    SBC: CBT4CBT LLC            Topic: R42

    The goal of this fast track STTR proposal is to expand buprenorphine maintenance therapy for opioid dependent patients Over million people in the US are addicted to opiates Providing effective agonist therapy methadone or buprenorphine coupled with behavioral counseling greatly improves outcomes reduces morbidity and reduces societal costs Methadone maintenance treatment has been limit ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
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