Award Data

DESCRIPTION (provided by applicant): The goal of this study is to create easy-to-use interactive computer simulation software that analyzes residency scheduling alternatives that comply with the requirements of the Accreditation Council for Graduate Medical Education. The new guidelines constrain the number of days and hours that residents are available to work in teaching hospitals. Therefore ...

Physitron proposes the development of a Thermal Neutron Beam Concentrator for use in detecting strategic nuclear material (SNM) such as U, Pu, Th, etc. A compact neutron generator developed by Lawrence Berkeley National Lab will provide 2.4 MeV neutrons that will be moderated, concentrated into a high flux beam, and propagated in air across distances up to three meters. Any SNM in the beam's path ...

DESCRIPTION (provided by applicant): Electronic medical record systems (EMR) are held back because data entry is slow, expensive, and codified in a format unsuitable for relational database repositories. Medical Reporting Solutions has developed advanced technology, which can overcome these problems through new methods to encode knowledge in medical reports, and a domain specific speech recogni ...

DESCRIPTION (provided by applicant): Age-related macular degeneration (AMD) is the leading cause of blindness in the Western world. The hallmark of the disease is retinal pigment epithelial (RPE) dysfunction with subsequent death of the foveal photoreceptors. Hematopoietic stem cells (HSC) have been demonstrated to repair damaged tissues including heart muscle and nerve under selected conditions. ...

DESCRIPTION (provided by applicant): Age-related macular degeneration (AMD) is the leading cause of blindness in the Western world. The hallmark of the disease is retinal pigment epithelial (RPE) dysfunction with subsequent death of the foveal photoreceptors. Hematopoietic stem cells (HSC) have been demonstrated to repair damaged tissues including heart muscle and nerve under selected conditions. ...

DESCRIPTION provided by applicant Pulmonary drug delivery has emerged as a noninvasive alternative route for the treatment of lung diseases asthma COPD CF and lung cancer In order to obtain the desired level of effectiveness and safety of the inhaled drugs an appropriate deposition on the targeted region and subsequent absorption in the targeted region is vital Multiscale multidisciplin ...

DESCRIPTION provided by applicant Drug resistance to HIV is a major threat to achieving long term viral suppression in HIV individuals Up to of newly infected individuals acquire HIV with resistance to at least one of the major antiretroviral classes and incomplete viral suppression and virologic failure are often associated with drug resistance Therefore current DHHS guideline recomme ...

DESCRIPTION (provided by applicant): The purpose of this study is to develop an interactive PC computer game (with a working title of "Escape From Nicotinia") that will encourage young girls, ages 8-12, to make sound and informed decisions concerning smoking, and thereby prevent initiation of smoking and subsequent nicotine addiction. The specific aims for Phase I are to: create a preliminary desi ...

DESCRIPTION (provided by applicant): Major limitations in liver transplantation are primary graft failure leading to consumption of the already small donor pool. ATP depletion has been proposed to be involved in graft failure due to both prolonged storage and to transplantation of marginal fatty livers: Our recent developments of a fusogenic lipid vesicles that deliver ATP are therefore a prom ...

DESCRIPTION (provided by applicant): Expression and purification of cancer-associated proteins are prerequisite steps necessary to study their functions, structures, and interactions. However, these steps are often challenging or even infeasible due to poor protein solubility. Currently, various strategies exist for improving recombinant protein solubility, but many proteins are still poorly so ...