Award Data

DESCRIPTION provided by applicant The overall goal of this project is to demonstrate the ability of our acute myocardial infarct selective paramagnetic contrast agent Gadolinium ABE DTTA to differentiate between acute and chronic infarcts in a reliable manner using contrast enhanced magnetic resonance imaging ceMRI In our Phase I data we have shown that Gd ABE DTTA exclusively highlight ...

DESCRIPTION (provided by applicant): A high percentage of the ~ 500,000 children born prematurely each year in the US require intravenous feeding after birth because they do not tolerate oral feeding. This is accomplished with a total parenteral nutrition (TPN) solution, which is prepared from component solutions: small and large volume parenterals (SVPs and LVPs). Aluminum (Al) is a common contam ...

Develop a high power to weight, compact, heavy fuel MCC engine using advanced high strength materials. This new MCC engine design will also offer high durability and high efficiency with an extremely low acoustic and IR signature for use in future small UAVs. The overall objective of this Phase I development program is to develop a JP-5, JP-8 or DS2 MCC engine using advanced high strength to weigh ...

In this proposed SBIR program, IBC Materials & Technologies, in conjunction with our industry partner Mechanical Solutions, Inc. (MSI) and Texas A&M University, will leverage our knowledge and experience in the domain of industrial metallic coatings to develop a metallurgical coating solution for the Air Foil Bearing. IBC has deep expertise in a variety of industrial coating processes including mu ...

DESCRIPTION provided by applicant Drug resistance to HIV is a major threat to achieving long term viral suppression in HIV individuals Up to of newly infected individuals acquire HIV with resistance to at least one of the major antiretroviral classes and incomplete viral suppression and virologic failure are often associated with drug resistance Therefore current DHHS guideline recomme ...

DESCRIPTION (provided by applicant): Molecular interactions are central to the understanding of basic biology and cellular function, are paramount to all molecular assays (research and in vitro diagnostics), are essential in biomarker discovery and critical toward evaluating therapeutics. However, the tools available to quantify these interactions have limitations, in so far as they either rely up ...

DESCRIPTION provided by applicant Cancer is a major public health problem and a leading cause of mortality claiming more than half million lives every year in the US While major progresses have been made in developing targeted anticancer therapeutics many cancers such as lung cancers have no effective treatments Unfortunately many ideal oncogenic targets including transcription factors for ...

DESCRIPTION (provided by applicant): Pancreatic islet transplantation is a viable approach for the treatment of type 1 diabetes (T1D). However, this therapeutic approach suffers from graft rejection. Dr. Shirwan, founder of ApoImmune, has developed a novel immunotherapeutic approach aimed at tolerance induction to alloantigens without chronic use of general immunosuppression. This approach, terme ...

DESCRIPTION provided by applicant Problem Lower gastrointestinal bleeding is a significant medical problem in the United States accounting for more than hospital admissions and tens of billions of dollars of healthcare spending annually It is common for bleeding from a single site to stop and restart multiple times The three modalities now used to diagnose and locate gastrointestina ...

The challenge has been set to meet Navy’s renewable fuel standard using advanced biofuels. Microalgae, along with other future fuel crops, must be aggressively developed now, not later. Recent dramatic demonstrations with algae based biodiesel and biojet show that it is no longer a question of algae being suitable as a natural source of oils that can be refined to produce biofuels. Rather, it is ...