Award Data

DESCRIPTION provided by applicant Kinase inhibitors created a new paradigm in chemotherapy and are a major focus of new oncology drug development The Bcr Abl inhibitor imatinib was a breakthrough drug for chronic myelogenous leukemia with overwhelming early results however at least of patients are either intolerant resistant or experience recurrence within years and individual respo ...

In this proposed SBIR program, IBC Materials & Technologies, in conjunction with our industry partner Mechanical Solutions, Inc. (MSI) and Texas A&M University, will leverage our knowledge and experience in the domain of industrial metallic coatings to develop a metallurgical coating solution for the Air Foil Bearing. IBC has deep expertise in a variety of industrial coating processes including mu ...

DESCRIPTION provided by applicant Drug resistance to HIV is a major threat to achieving long term viral suppression in HIV individuals Up to of newly infected individuals acquire HIV with resistance to at least one of the major antiretroviral classes and incomplete viral suppression and virologic failure are often associated with drug resistance Therefore current DHHS guideline recomme ...

DESCRIPTION provided by applicant Development of novel lung cancer therapeutics targeting the DNA damage response Abstract Lung tissue is constantly exposed to a wide variety of inhaled chemical agents While the majority of these maybe innocuous those that damage DNA have severe consequences Thus the DNA damage response DDR and DNA repair in these tissues is extremely important The vast ...

Terrorist use of radioactive nuclear materials via nuclear and/or radiological dispersion devices (dirty bombs) is a serious threat. Therefore, it is critical to detect the proliferation of nuclear material. Critical challenges facing this objective include: (a) high sensitivity detection of signature emissions (e.g., gamma rays) from common radioactive isotopes behind shielding, and (b) cost-effe ...

DESCRIPTION provided by applicant Cancer is a major public health problem and a leading cause of mortality claiming more than half million lives every year in the US While major progresses have been made in developing targeted anticancer therapeutics many cancers such as lung cancers have no effective treatments Unfortunately many ideal oncogenic targets including transcription factors for ...

There is an unmet demand for ultra-low-power, ultra-compact and low-cost radios to address emerging sensing and communication needs for military and commercial applications such as IoT/IoE. To overcome the limitations in existing bulky and power hungry radios, we propose a disruptive solution by integration of a nano-scaled THz transceiver, on-chip antenna, and energy harvesting circuits in a form ...

ABSTRACT: A range segment upgrade for Air Force satellite control network (AFSCN) will significantly improve system effectiveness via spectrum sharing and seamless interoperation. However, the upgraded system requires new capabilities such as real-time and accurate RF interference detection and mitigation, array antenna backlobe/sidelobe suppressions, accurate performance degradation prediction, ...

DESCRIPTION provided by applicant Problem Lower gastrointestinal bleeding is a significant medical problem in the United States accounting for more than hospital admissions and tens of billions of dollars of healthcare spending annually It is common for bleeding from a single site to stop and restart multiple times The three modalities now used to diagnose and locate gastrointestina ...

Miniaturized base metal electrodes (BME) multilayer ceramic capacitors (MLCC) are of great interest for future missile applications as designers are striving to achieve smaller, lighter, cheaper, faster and better electronic assemblies without sacrificing long-term performance. Unfortunately, screening, reliability and qualifications criteria are either not available or not standardized. In the ...