Award Data

PROJECT SUMMARY Aminoglycosides are one of the cheapest and well known antibiotics in clinical use for over years but one of the major limitations in their use is their ototoxicity We are developing fast and low cost methods to develop aminoglycosides with anti ribosomal activities and reduced toxicity In this project we will identify novel aminoglycoside antibacterials that show reduced ...

DESCRIPTION provided by applicant Each year million US children are injured affecting the child his her family and society which often bears the cost Among school age children age to injuries lead to million emergency department ED visits and hospital admissions annually resulting in $ billion in medical costs and $ billion more in work loss costs Approxima ...

A NEW HOLOGRAPHIC D CAMERA FOR FUNDUS IMAGING Abstract In the United States retinal disease is the most common cause of visual impairment with age related macular degeneration AMD and diabetic retinopathy DR being the most common retinal diseases For each of the above conditions high resolution and three dimensional D imaging of the retina retinal vasculature choroid and or retinal ...

DESCRIPTION provided by applicant Neonatal and pediatric intensive care still involves performing painful needle punctures to obtain blood samples for routine clinical monitoring Pain management in the neonatal setting is often achieved by long term continuous intravenous infusion of morphine or related compounds It has become increasingly clear however that long term use of opioid compound ...

Project Summary Abstract Seasonal influenza has an annual global incidence of up to in adults and up to in children About to million infections result in severe disease while somewhere between a quarter and a half million cases are fatal Antiviral drugs can lessen the severity and reduce mortality when administered within h of onset of symptoms Hence sensitive and specific poin ...

DESCRIPTION provided by applicant Problem Lower gastrointestinal bleeding is a significant medical problem in the United States accounting for more than hospital admissions and tens of billions of dollars of healthcare spending annually It is common for bleeding from a single site to stop and restart multiple times The three modalities now used to diagnose and locate gastrointestina ...

DESCRIPTION provided by applicant This proposal is in response to PA the parent announcement for STTR R grant applications Hematopoietic stem cell transplantation has become a preferred treatment for hematological malignancies and certain genetic disorders The use of umbilical cord blood cells as a source of hematopoietic stem cells for bone marrow transplantation has increased st ...

PROJECT SUMMARY The overall goal of the proposed research and technology transfer effort is to develop a low cost point of care mobile device based technology for automated identification of Stillandapos s murmur the most common innocent benign and harmless heart murmur of childhood This novel technology could reduce the current rate of over a million children unnecessarily referred to pedia ...

DESCRIPTION provided by applicant This proposal is for a phase I II fast track project for the STTR program with the main goal to develop a blood test for Alzheimerandapos s disease AD diagnosis AD is the most common dementia in the elderly population and one of the leading causes of death in the developed world One of the main problems in AD is the lack of an early sensitive and objective ...

DESCRIPTION provided by applicant The ebolaviruses and Marburg virus MARV constitute the family Filoviridae andquot filovirusesandquot that cause severe hemorrhagic fever with human case fatalities of The current epidemic in West Africa unprecedented in terms of geographic scope and size highlights the continued need for development of therapeutics Among the five ebolavirus spe ...