Award Data

Pain is the single greatest cause of disability and its management remains one of medicine s foremost challenges Potent opiates can effectively reduce the severity of pain thereby diminishing patient suffering Unfortunately chronic use of these drugs can be harmful to patients whether by inadvertent overdosing unintentional addiction or abuse resulting from dependency on the euphoric effec ...

Project Summary Stroke is the th leading cause of death and number one cause of adult disability in the United States The primary goal of ischemic stroke treatment is quickly restoring blood perfusion However studies have shown that this return of blood flow while necessary can also cause damage to local tissue Hypothermia has been shown to decrease this reperfusion injury The overall go ...

DESCRIPTION provided by applicant This Phase STTR will develop novel techniques for coronary sinus access The coronary sinus provides unique anatomic and physiologic proximity to all four cardiac chambers and the coronary circulation For example the coronary sinus is used for left ventricular lead insertion for biventricular pacing or cardiac resynchronization Mor than such implan ...

DESCRIPTION provided by applicant The emerging light based imaging technique of acoustic resolution photoacoustic endomicroscopy AR PAEM enables visualization of subsurface tissues with microscopic resolution at depths of many millimeters AR PAEM images provide crucial information regarding microvasculature morphology and tissue physiology blood oxygenation For cancers originating in ...

DESCRIPTION provided by applicant Cardiovascular diseases and Asthma affects between and million people in the United States including million children during the past years its incidence worldwide has doubled Asthma is responsible for million person days of restricted activity and deaths per year amounting to $ billion in direct heath related costs there is uncertainty about the specific factors ...

In prior research and development, the team developed AlphaBear, a mobile gaming app where students are challenged to spell words which are then used to create humorous sentences. This project will develop and test a prototype for use specifically by English Learners. The prototype will formatively assess students' vocabulary, adjust gameplay to the skill levels of individual students, and provide ...

DESCRIPTION provided by applicant Pulmonary drug delivery has emerged as a noninvasive alternative route for the treatment of lung diseases asthma COPD CF and lung cancer In order to obtain the desired level of effectiveness and safety of the inhaled drugs an appropriate deposition on the targeted region and subsequent absorption in the targeted region is vital Multiscale multidisciplin ...

DESCRIPTION provided by applicant The blood brain barrier BBB is a tight barrier formed by microvessels and capillaries that control the passage of nutrients fluids metabolic products and drugs between the blood and the brain Impaired function of the BBB is involved in a number of major pathologies afflicting the brain such as Alzheimerandapos s disease multiple sclerosis Parkinsonanda ...

Abstract The ultimate goal of the proposed research is to develop a multiplex assay for early detection of Cutaneous T Cell Lymphoma CTCL in human serum or plasma Mycosis fungoides MF is a slowly progressive form of CTCL that initially manifests by non specific cutaneous eczematous patches and plaques similar to atopic dermatitis eczema psoriasis and other benign dermatoses The early d ...

DESCRIPTION provided by applicant Bleeding complications occurred in approximately of surgical procedures In trauma to of deaths are related to uncontrolled bleeding Blood transfusions and reoperations are used to mitigate bleeding and avert death however these procedures can be costly and are associated with complications Blood transfusion can lead to nosocomial infection im ...