Award Data

DESCRIPTION provided by applicant There is growing awareness that weakness of muscle is a significant biomedical health issue associated with many different chronic diseases and aging There are a variety of different diseases that affect muscle including muscular dystrophy fibromyalgia cerebral palsy amyotrophic lateral sclerosis and myasthenia gravis each of which carries its own uniqu ...

As the power density of advanced engines increases, the need for new materials that are capable of higher operating temperatures, such as ceramic matrix composites (CMCs), is critical for turbine hot-section static and rotating components. Such advanced materials have demonstrated the promise to significantly increase the engine temperature capability relative to conventional super alloy metallic ...

Recurring slope linae (RSL), such as those in Newton Crater on Mars, methane plumes in hazardous Martian terrain, and water ice discovered during the LCROSS experiment in the Moon?s permanently shadowed Cabeus Crater drive the need for a new generation of robotic explorers that access, probe, extract, and return resources from extreme terrains. These robots must possess sufficient system-level aut ...

The program is focused on developing high temperature energy harvesting devices that can convert waste energy (primarily vibratory) such as the mechanical disturbance from thrusters as to include waste exhaust created during operational conditions. The program focus is on developing very high performance devices that are extremely robust and that can continuously operate at up to 500 C. The purpos ...

High-energy space radiation from Galactic Cosmic Rays and Solar Particle Events (SPEs) pose significant risks to equipment and astronaut health in NASA missions. Energetic particles from SPEs associated with flares and coronal mass ejections (CMEs) may adversely affect not only beyond-Low-Earth-Orbit missions, but also aircraft avionics, communications, and airline crew/passenger health. It is cru ...

DESCRIPTION provided by applicant Insulin resistance IR also known as metabolic syndrome is tied to obesity and is associated with numerous modern health problems including the growing problems of type diabetes and cardiovascular disease The growing health economic and social burdens of these conditions calls for the need to develop drug treatments for IR We know from multiple lines of ...

The modern warfighter faces the constant threat of endemic infections, multi-drug resistant bacteria and Biological Warfare Agents. In order to provide accurate front-line treatment that will curtail the overuse of antibiotics, a rapid and robust molecula

DESCRIPTION provided by applicant Studies in the pediatric intensive care unit PICU have shown that hypoglycemia hyperglycemia as well as swings in blood glucose levels are strongly associated with higher morbidity and mortality However tight glucose control has not been proven as effective In fact hypoglycemia was found to be a real danger Thus there is a need for more careful study ...

Establish a radiation-aware analysis capability in a commercial EDA design flow that will enable first-pass success in radiation-hardened by design (RHBD) for DoD ASICs in much the same way that existing EDA design suites ensure first pass functionality and performance success of complex ASICs destined for commercial applications. Layout-aware, calibrated single-event radiation models that captur ...

Project Summary Crystallization followed by subsequent structure determination is a major step in understanding the structure function relationship of macromolecules Understanding macromolecule structure has become a key part in the development of new pharmaceuticals and is a major area of NIH research Crystallization however is also the rate limiting step despite technological efforts to a ...