Award Data

PROJECT SUMMARY Aminoglycosides are one of the cheapest and well known antibiotics in clinical use for over years but one of the major limitations in their use is their ototoxicity We are developing fast and low cost methods to develop aminoglycosides with anti ribosomal activities and reduced toxicity In this project we will identify novel aminoglycoside antibacterials that show reduced ...

DESCRIPTION provided by applicant Problem Lower gastrointestinal bleeding is a significant medical problem in the United States accounting for more than hospital admissions and tens of billions of dollars of healthcare spending annually It is common for bleeding from a single site to stop and restart multiple times The three modalities now used to diagnose and locate gastrointestina ...

Principal Investigators for Small BusinessDiscoveryBioMedIncDBMand Monell Chemical Senses Center Project Summary Abstract Bitter taste in foods and medicines presents a barrier to overcoming global public health challengesfood insecuritypoor nutritional healthand poor compliance with medication useparticularly among children and the elderlySugar and saltthe mainstays to address these challengesfur ...

This SBIR project will develop and demonstrate efficient electron emitter based on carbon nanotubecopper (CNT-Cu) composite for passive discharging of spacecraft in plasma environment. A spacecraft moving through harsh plasma environment collects electrons, which leads to the spacecraft charging up to several kilovolts. High voltage between different parts of the spacecraft can ignite arcing, whic ...

Traumatic brain injuryTBIis a substantial health care issue affecting both civilian and military populationsAlthough extremes of head injury are recognizablemild to moderate TBImmTBIis more difficult to diagnose leading to a need for the identification of circulating biomarkers of brain injury that may facilitate early identificationUsing a rat model of TBI we identified a novel marker of neuronal ...

High speed air vehicles operate at material strength performance limits and are at significant risk when subjected to additional localized heating that can result in softening, pitting and burn-through the material and potentially change the vehicle structural profile. These effects degrade aerodynamic performance. The team of CFDRC and UDRI proposed to develop, validate and deliver a comprehensiv ...

There are many challenges in creating Air Force systems that are resilient against cyber threats. The cyber environment and its threats are highly dynamic, requiring practices and training to be dynamic as well. Cyber threats must be considered during th...

Oceanit proposes to develop a system to characterize weak electromagnetic fields for the investigation of the effect of both thermal and non-thermal RF/magnetic fields on biological material, and to detect resulting biological impact of the energy deposited.

DESCRIPTION provided by applicant Therapeutics is focused on the development of adjuvant systems with desired immune activities for targeted indications The Companyandapos s immune stimulatory adjuvant platform builds on combinatorial use of immune agonists with distinct immune targets and mechanisms of action for the generation of therapeutic immune responses Critical to this platform techno ...

Next-generation turbulent combustion models must enable accurate prediction of lean blow-out and flashback for complex geometries, fuels and operating conditions relevant to the Air Force. Improved models are needed to better predict kinetically and hydr...