Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. A microfluidic platform for modeling drug transport and cell trafficking across the blood brain barrier

    SBC: Nortis, Inc.            Topic: 105

    DESCRIPTION provided by applicant The blood brain barrier BBB is a tight barrier formed by microvessels and capillaries that control the passage of nutrients fluids metabolic products and drugs between the blood and the brain Impaired function of the BBB is involved in a number of major pathologies afflicting the brain such as Alzheimerandapos s disease multiple sclerosis Parkinsonanda ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  2. A New Technique for Diabetic Foot Ulcers

    SBC: Noveratech LLC            Topic: 200

    ABSTRACT Diabetes is the leading cause of nontraumatic lower extremity amputations in the United States Diabetic foot ulcers DFUs are responsible for more hospitalizations than any other diabetic complications Currently even the best available treatments achieve only a healing rate for these wounds and this healing is often only temporary with a chance of recurring Our company has ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  3. AlphaBear

    SBC: Spry Fox LLC            Topic: 1

    In prior research and development, the team developed AlphaBear, a mobile gaming app where students are challenged to spell words which are then used to create humorous sentences. This project will develop and test a prototype for use specifically by English Learners. The prototype will formatively assess students' vocabulary, adjust gameplay to the skill levels of individual students, and provide ...

    SBIR Phase I 2016 Department of Education
  4. A mechanism based computational tool to optimize pulmonary drug delivery

    SBC: CFD Research Corporation            Topic: 300

    DESCRIPTION provided by applicant Pulmonary drug delivery has emerged as a noninvasive alternative route for the treatment of lung diseases asthma COPD CF and lung cancer In order to obtain the desired level of effectiveness and safety of the inhaled drugs an appropriate deposition on the targeted region and subsequent absorption in the targeted region is vital Multiscale multidisciplin ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  5. An Active Hemostatic Clamping Device for Bloodless Surgery and Trauma

    SBC: NOVUSON SURGICAL, INC.            Topic: 300

    DESCRIPTION provided by applicant Bleeding complications occurred in approximately of surgical procedures In trauma to of deaths are related to uncontrolled bleeding Blood transfusions and reoperations are used to mitigate bleeding and avert death however these procedures can be costly and are associated with complications Blood transfusion can lead to nosocomial infection im ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Chikungunya Recombinant Subunit Vaccine

    SBC: Hawaii Biotech, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Chikungunya virus CHIKV is an alphavirus classified as a category C priority pathogen that causes fever rash and arthralgia in humans In the past decade CHIKV outbreaks have spread beyond the endemic regions of Africa and Asia first to the islands in the Indian Ocean and most recently to the Americas The World Health Organization has reported that as ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Development of An Integrated High Throughput Imaging and Image Analysis Platform for Muscle

    SBC: CytoInformatics LLC            Topic: NIA

    DESCRIPTION provided by applicant There is growing awareness that weakness of muscle is a significant biomedical health issue associated with many different chronic diseases and aging There are a variety of different diseases that affect muscle including muscular dystrophy fibromyalgia cerebral palsy amyotrophic lateral sclerosis and myasthenia gravis each of which carries its own uniqu ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Development of novel isoflavone drugs as broad spectrum antivirals

    SBC: KINETA, INC.            Topic: R

    DESCRIPTION provided by applicant Kineta has discovered a novel class of broad spectrum small molecule antivirals that function through a host directed mechanism These compounds have demonstrated an innovative mechanism of action and target several high priority pathogens that are commercially valuable The lead chromenone based candidates have potency in the nM range inhibit multiple viruses ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Development of Tumor Proliferation PET Tracer FLT using a Low Cost Single Dose Automatic Production and Quality Control Biomarker Generator System

    SBC: ABT Molecular Imaging            Topic: 102

    DESCRIPTION provided by applicant Worldwide a person dies from cancer every seconds Positron emission tomography PET is an effective tool that is critical in diagnosing cancer and monitoring treatment efficacy PET imaging relies on use of short lived radioisotopes Commercial distribution of the most commonly used radio tracer F FDG has resulted in patient population coverage in ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Exploiting Natural Products-Based Therapeutics for Aflatoxin Mitigation

    SBC: CFD Research Corporation            Topic: CBD152003

    Aflatoxins are a paradigm among fungal produced mycotoxins that are present in food supplies and are strongly associated with increased risk forthe development of hepatocellular carcinoma. Currently, there are no known countermeasures that can selectively mitigate aflatoxin toxicity andthe available options are only symptomatic treatments. To meet this challenge, we propose to harness the microbio ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
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