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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Novel sanitizer/disinfectants against viral infections with long-lasting effect

    SBC: CAMELLIX, LLC            Topic: NIAID

    AbstractNorovirus is the most common cause of acute gastroenteritis in the United Statesassociated annually withmillion illnesseshospitalizations anddeathsUS CDCOverview about NorovirusNorovirus is one of the nonenveloped viruses that are resistant to alcohol sanitizationAccording to US CDC Guidelines for the Prevention and Control of Norovirus Gastroenteritis Outbreaks in Healthcare Settingsthe p ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. The Diagnostic Utility of the in-vitro "Provoked" D dimer test in patients with suspected pulmonary embolism

    SBC: AUGdimer LLC            Topic: NHLBI

    Project SummaryThe D Dimer assay is the current diagnostic standard to exclude patients of VTE due to its high sensitivityHoweverD Dimer levels are commonly elevated in patients without thromboembolismleading to poor specificity and poor positive predictive valuePPVDue to the lack of a robust diagnostic tool for VTEwe propose a novel advancement upon current DDimer testing which improves specifici ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. A Tissue Support Structure (Macular O-Rings) for Reconstructing, Translocating or Transplanting Three-Dimensional Submacular Tissue Organoids in Age Related Macular Degeneration (AMD)

    SBC: iMacular Regeneration LLC            Topic: NEI

    Project Summary Abstract Age related macular degenerationAMDis a leading form of irreversible blindnessiMacular Regeneration LLCiMac Regenwill introduce a novel tissue support structuremacular O rings or MORsmade from a biocompatibleimplantable materialnitinol or nickel titanium alloyThe surgical deviceMORwill be tested both ex vivo and in vivo for proof of concept in this phase I STTR studyThe de ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a Novel Bio-Adhesive Mesh System for Abdominal Hernia Repair

    SBC: CIRCA BIOSCIENCE, LLC            Topic: 300

    Development of a Novel Bio Adhesive Mesh System for Abdominal Hernia Repair Project Summary Abstract This project proposes the development of a novel mesh adhesive system for abdominal hernia repair utilizing surface modification of polymer surgical mesh to allow for improved tissue fixation with a poloxamine hydrogel adhesiveMore thanmillion Americans undergo hernia repair with surgical mesh each ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Prevention of type 1 diabetes using early glycation products

    SBC: HGG Research LLC            Topic: 200

    PROJECT SUMMARY TypediabetesT Da devastating and expensive organ specific autoimmune disease once afflicting mainly juvenilesis increasing in incidence among US adults withexcess risk of death in womenThe long term objective of this project is to develop a preventive and complementary strategy for T D management that is non invasivelong lastingand low costEarly glycation productsEGPsgenerated in t ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Developing and validating a podocyte cell-based diagnostic assay for identifying recurrent focal and segmental glomerulosclerosis patients

    SBC: InDepth Pharmaceuticals, LLC            Topic: 400

    Diagnosing glomerular diseases accurately and in timely fashion is key to developing a successful treatment plan and thereby prevent their progression to ESRDend stage renal diseaseHowevertheir successful diagnosis remains challenging due to the complex diagnostic procedures used including invasive renal biopsiesThusthere is a compelling need to develop simplified procedures to detect glomerular d ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Production and Characterization of Human Immunoglobulin Producing Goats for Diagnostic Reagents and Therapeutics

    SBC: SAB Capra LLC            Topic: NIAID

    Project Summary Abstract The ultimate goal of this phase II STTR proposal is to expand the capabilities of SABandapos s diversitAbplatform by continuing advanced development of Transchromosomic goatsTcGsThis will be accomplished by producing male and female goat endogenous immunoglobulin gene knockout cell lines that contain SAB Capraandapos s human artificial chromosomeHACwhich encodes the entire ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. HIGH RECOVERY RATE AND HIGH PURITY ENRICHMENT OF CIRCULATING TUMOR CELLS

    SBC: FCS Technology LLC            Topic: NIBIB

    Project Summary Abstract Circulating tumor cellsCTCsare cancer cells that are detached from primary solid tumors and carried through the vasculature to potentially seed distant site metastases in vital organsthe main cause of death by cancerSingle cell molecular characterizations and analyses of CTCs not only could benefit basic cancer researchbut also might eventually lead to a more effective can ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Microneedle Based Targeted Allergen Specific Immunotherapy for Treatment of Peanut Allergies

    SBC: Moonlight Therapeutics, Inc.            Topic: NIAID

    Microneedle Based Targeted Allergen Specific Immunotherapy for Treatment of Peanut Allergies Food allergies affectmillion people in the USA andmillion in EuropeSix million childrenroughlyinin the USA have at least one food allergythis equates to at leastin every classroomCurrentlythere are no approved therapies for food allergies anywhere in the worldFood allergies are expected to growannually unt ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Pulmonary valved conduit xenograft with regeneration potential

    SBC: TGen Tech, LLC            Topic: NHLBI

    Congenital heart disease affects approximatelynewborns each year in the U SValve and conduit replacements are needed for absent pulmonary valveaortic stenosisKonno procedureRoss proceduredouble outlet right ventricleRastelli operationextracardiac conduitFontan operationpulmonary valve replacementTetralogy of FallotMaterials in current use include homograft blood vesselsglutaraldehyde treated bovin ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health

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