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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of a Novel Bio-Adhesive Mesh System for Abdominal Hernia Repair

    SBC: CIRCA BIOSCIENCE, LLC            Topic: 300

    Development of a Novel Bio Adhesive Mesh System for Abdominal Hernia Repair Project Summary Abstract This project proposes the development of a novel mesh adhesive system for abdominal hernia repair utilizing surface modification of polymer surgical mesh to allow for improved tissue fixation with a poloxamine hydrogel adhesiveMore thanmillion Americans undergo hernia repair with surgical mesh each ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Developing and validating a podocyte cell-based diagnostic assay for identifying recurrent focal and segmental glomerulosclerosis patients

    SBC: InDepth Pharmaceuticals, LLC            Topic: 400

    Diagnosing glomerular diseases accurately and in timely fashion is key to developing a successful treatment plan and thereby prevent their progression to ESRDend stage renal diseaseHowevertheir successful diagnosis remains challenging due to the complex diagnostic procedures used including invasive renal biopsiesThusthere is a compelling need to develop simplified procedures to detect glomerular d ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Production and Characterization of Human Immunoglobulin Producing Goats for Diagnostic Reagents and Therapeutics

    SBC: SAB Capra LLC            Topic: NIAID

    Project Summary Abstract The ultimate goal of this phase II STTR proposal is to expand the capabilities of SABandapos s diversitAbplatform by continuing advanced development of Transchromosomic goatsTcGsThis will be accomplished by producing male and female goat endogenous immunoglobulin gene knockout cell lines that contain SAB Capraandapos s human artificial chromosomeHACwhich encodes the entire ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Evolution of an Adaptable Prosthetic Foot Design for Normalization of Biomechanics During Community Participation

    SBC: OHIO WILLOW WOOD COMPANY, THE            Topic: NICHD

    Evolution of an Adaptable Prosthetic Foot Design for Normalization ofBiomechanics During Community Participation Summary AbstractThe vision of this project is to improve the functional physical mobility of people with lower extremity amputations especially on uneven groundside slopes or when foot placement varies from side to sidePeople with amputations will be enabled to confidently participate i ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Enabling dexterous surgery at the tip of a flexible endoscope: A low-cost, disposable, steerable sheath.

    SBC: EndoTheia, Inc.            Topic: NIBIB

    Project Summary AbstractThe objective of this proposal is to perform proof of concept experiments for a new thin walledsteerable sheath that can pass through a standard colonoscope port and dexterously maneuver surgical instruments at its tipClinical significance comes from the fact that overpatients per year in the USA have unnecessaryinvasive surgery to remove a section of their colonClinical li ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Compatibility between Brain-Computer Interface and High-Efficiency Augmentative and Alternative Communication Systems

    SBC: Prentke Romich Company            Topic: NIDCD

    Compatibility Between Brain Computer Interface and High Efficiency Augmentative and Alternative Communication SystemsPhase II ABSTRACTBrain computer interfacesBCIenable text production for people who cannot movebut have only simple communication interfaces and are not widely usedAugmentative and alternative communicationAACsystems are widely used and give efficient and precise communicationbut req ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Fully Human Antibody Combinations for the Prevention of Seasonal Influenza Infection

    SBC: IDBiologics, Inc.            Topic: NIAID

    Our overarching goal is to develop a monoclonal antibody based product for the prevention of seasonal influenza in high risk patientsIt is estimated there aredeaths annually related to seasonal influenza worldwideIn the United Statestheinfluenza season was classified a high severity season withdeathsandhospitalizations attributed to influenzaserving as a reminder of the continued severity of influ ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Extending WAAVES+: An animal and environment-agnostic, automated USV scoring platform for high-throughput social, behavioral, and neuropharmacological studies

    SBC: Cornerstone Research Group, Incorporated            Topic: 101

    Project SummaryUltrasonic vocalizationsUSVsare known to reflect emotional processingbrain neurochemistry and brain functionkey observations in animal model studiesCollecting and processing USV data is time intensivemanualand costlyMost importantlyit limits researchersability to employ fully effectiveand nuanced experimental designsand is a barrier to entry for other researchersAutomated tabulation ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Evaluation of therapeutic efficacy and safety of novel small RNA target delivery platform in vivo.

    SBC: Oncoimmune Inc            Topic: 100

    Project Summary AbstractThe recent rapid expansion of genomic data greatly contributes to the understanding of disease development and progressionTo translate these genetic discoveries into clinical applicationswe need to develop therapeutic platforms that can specifically modulate the expression of disease related genes in vivoSmall RNAssuch as microRNAs and siRNAs function in messenger RNA silen ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. LystaMab Immunotherapy to Inhibit Pericardial Adhesions

    SBC: Lyst Therapeutics LLC            Topic: NHLBI

    SUMMARY Despite significant advances in the surgical and medical management of congenital heart diseasecongenital cardiac anomalies remain a leading cause of death in the newborn periodMost severe forms of congenital heart disease require multiplestaged surgical interventionsA significant source of the heightened morbidity and mortality associated with these operations is the development of cardia ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health

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