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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Whole Tooth Tissue Engineering

    SBC: Dentigenix            Topic: N/A

    DESCRIPTION: The long-term objective of this project is to engineer biological tooth substitutes that can be used to replace missing, diseased or injured human teeth. The approach, based on recent successful tissue engineering efforts, is to seed single cell suspensions derived from immature tooth buds onto biodegradable polymer scaffolds, and to implant the seeded scaffolds in the omentum of rat ...

    STTR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  2. UTERINE TUMOR TREATMENT USING HIGH INTENSITY ULTRASOUND

    SBC: SONIC CONCEPTS, INC.            Topic: N/A

    DESCRIPTION (provided by the applicant): High Intensity Focused Ultrasound (HIFU) offers a non-invasive, non-surgical, bloodless, outpatient treatment for uterine fibroid tumors. These tumors develop in over half of all women, and account for approximately 30 percent of all hysterectomies. This proposal will develop an integrated transvaginal HIFU probe and imaging transducer for fibroid treatment ...

    STTR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  3. UTERINE TUMOR TREATMENT USING HIGH INTENSITY ULTRASOUND

    SBC: SONIC CONCEPTS, INC.            Topic: N/A

    DESCRIPTION (provided by the applicant): High Intensity Focused Ultrasound (HIFU) offers a non-invasive, non-surgical, bloodless, outpatient treatment for uterine fibroid tumors. These tumors develop in over half of all women, and account for approximately 30 percent of all hysterectomies. This proposal will develop an integrated transvaginal HIFU probe and imaging transducer for fibroid treatment ...

    STTR Phase II 2002 Department of Health and Human ServicesNational Institutes of Health
  4. Use of Microarray Test Data for Toxicogenomic Prediction

    SBC: YAHSGS LLC            Topic: N/A

    DESCRIPTION (provided by applicant): This project bridges the understanding between physical and chemical principles and genomic/proteomic response by integrating three independent parallel toxicity prediction tools. Each uses computational neural networks (CNNs) and wavelets to rapidly and accurately make pharmaceutical/chemical toxicity predictions. A CNN-based Quantitative Structure-Activity ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  5. Ultra-Sensitive Diagnosis of AIDS-Related Tuberculosis

    SBC: AttoDx, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant This grant will develop a novel strategy to enhance the analytical sensitivity of polymerase chain reaction PCR based detection of bacteria in samples We will commercialize the strategy in the form of a pre PCR andquot turbo chargerandquot to be marketed in conjunction with PCR based molecular diagnostic systems The current STTR project will apply this str ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Ultra-high sensitivity, high spatial resolution single photon emission tomography using mechanical flux manipulation.

    SBC: PRECISION SENSING LLC            Topic: NIBIB

    The goal of this project is to develop both hardware and software to demonstrate the ground breaking capabilities of a new single photon radionuclide (SPR) imaging technique with the potential for andgt;1000 times gain in sensitivity and andgt;100 times gain in volumetric spatial resolution compared to clinical SPECT imaging using parallel-hole collimators. We refer to our new imaging methodology ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Translational development of specialized NK cells for cancer immunotherapy

    SBC: Indapta Therapeutic            Topic: 102

    Project Summary Abstract The annual incidence of head and neck cancers worldwide is more thancases with arounddeaths each yearand it is estimated that inthere will benew cases of non Hodgkin lymphoma with an estimateddeaths this yearIn this proposalwe describe a strategy to use a novel subset of natural killer cellsg NK cellsallogeneically for cancer therapyWe hypothesize that expansion and adopti ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Transcutaneous Acoustic Palpation (TAP): Pain Diagnosis

    SBC: ALLEZ PHYSIONIX, LTD            Topic: N/A

    DESCRIPTION (provided by applicant): Undiagnosed sources of pain are a frequent, though often a nonspecific presenting symptom of numerous medical conditions. A classic attempt to make pain a more specific diagnostic in conjunction with anatomical knowledge is when the Doctor palpates a particular part of the body and asks does this hurt? This works well enough for potential sources of pain at or ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  9. TRANSCRANIAL DOPPLER SIMULATOR FOR TRAINING AND ASSESSMENT

    SBC: SHEEHAN MEDICAL LLC            Topic: 101

    We aim to develop a transcranial Doppler TCD ultrasound simulator on a physical mannequin for realistic medical training and professional competence testing The Specific Aims of the project are Develop a prototype TCD simulator The anatomy of the cerebrovascular system CVS will be reconstructed in three dimensional D from a patient s computed tomography angiogram CTA The blood flow ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. TILLING Wheat for Reduced Celiac Disease Causing Proteins

    SBC: Anawah, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Celiac disease is an autoimmune digestive disorder in which intestinal lesions develop in genetically susceptible individuals in response to the ingestion of specific seed storage proteins found in cereal grains. The only treatment is strict adherence to a diet from which the offending grains have been eliminated. Therefore, considerable research has been devot ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
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