Award Data

Development of a high throughput screen to detect the effects of both preand postbiotransformed compounds for enhanced content drug discovery workflows Project Summary This Small Business Innovation Research Phase II project will build upon our successful Phase I demonstration that substrate free autobioluminescent signal generation can detect both the preand post biotransformed metabolic impacts ...

Because of its high sensitivitypolymerase chain reactionPCRis the gold standard for the diagnosis of many infectious diseasesbut generally only implemented in well equipped laboratoriesOne of the major roadblocks for expanding PCR to point of care markets is the lack of simplerobustsingle tube PCR designs which preserve its laboratory based high sensitivity and specificityIn this Fast Track STTR a ...

Expressing humanized bacterial luciferase in stem cellsMoving beyond firefly luciferase toexpand the informational capacity of animal models for regenerative medicine Project Summary This Small Business Technology TransferSTTRPhase II project proposes to develop complementary autonomously bioluminescentautobioluminescentin vitro stem cell lines and in vivo small animal model systems that enable th ...

Project Summary AbstractThe objective of this proposal is to transform a hand held surgical robotic system for transurethral laser prostate surgery from a lab prototype into a commercial productThe system will feature needle sized arms deployed through the endoscope port and will enable independent tissue manipulationlaser aimingand visualizationmaking surgery more accurate and ef cientClinical si ...

Solid oxide fuel cells have long suffered from degradation due to impurities in the fuel and complexities associated with dissimilar materials and high operating temperatures.This degradation lowers the usable cell power output and requires ancillary equipment for fuel sulfur removal and reformation.A unique microstructure for the tubular anode will be produced using a novel freeze-casting techniq ...

Wind tunnel testing of high performance aerodynamic systems, including force and moment measurements (of larger models), often involve unsteady oscillatory loads which may damage the expensive balance and would also normally impact the data accuracy and a

The Air Force has identified a need for a display agnostic common streaming model for 3D data. Third Dimension Technologies (TDT) and Oak Ridge National Laboratory (ORNL) have formed a consortium to define a 3D streaming model based on open standards for Display Agnostic 3D Streaming (DA3DS). Two factors are driving this need. The first is the dramatic increase in the collection, storage and trans ...

S-RAM Dynamics (S-RAM) proposes to design, fabricate, test, and commercialize a high-performance axial piston transcritical CO2 energy recovery compressor (ERC) to support next-generation aircraft thermal management systems for the U.S. Air Force and commercial applications. The S-RAM ERC will be developed and commercialized with the support of the Rolls-Royce Thermal Management System team and Pu ...

Hypersonic flight environments can include motion with high frequency spectral content that is difficult to simulate.This high frequency vibration may adversely affect the accuracy of guidance and control sensors, so it is very important to the Air Force Research Laboratory to be able to recreate the motion in a way that allows sensor performance to be evaluated.Motion platforms such as the KHILS ...

Diagnosis of relapsing remitting multiple sclerosisMSrests on clinical symptoms and examinations asoutlined in the revised McDonald s criteria supported by appropriate magnetic resonance imaging findings andother laboratory testsThe need for early diagnosis is clearly emphasized in a position paper produced inby MS Brain Health organization calledBrain healthTime matters in multiple sclerosiswhich ...