Award Data

A cerebral aneurysm is an abnormal enlargement or pouch that forms from a weakened vessel segment in the brain Often going unnoticed and untreated an aneurysm can cause a sudden and catastrophic hemorrhage or stroke Approximately of patients die from an aneurysm rupture even before receiving medical attention and of patients die despite medical treatment Patients that survive typical ...

PROJECT SUMMARY Chemotherapy induced peripheral neuropathy CIPN is a common prevalence and potentially dose limiting side effect of many cancer chemotherapy drug treatment regimens Clinically CIPN presents with pain that is burning shooting or electric shock like The increase in prevalence of cancer coupled with an increase in the cancer survival rates due to chemotherapy regimens ...

Because of its high sensitivity polymerase chain reaction PCR is the gold standard for the diagnosis of many infectious diseases but generally only implemented in well equipped laboratories One of the major roadblocks for expanding PCR to point of care markets is the lack of simple robust single tube PCR designs which preserve its laboratory based high sensitivity and specificity In this F ...

The long term objective of this project is the synthesis and assembly of wound healing devices that mimic as closely as possible the biochemical and mechanical characteristics of healthy human skin The proposed research would focus on the synthesis of membranes containing electrospun human recombinant tropoelastin and collagen mixtures The ratios of the two molecules and the spinning condition ...

Because of its high sensitivitypolymerase chain reactionPCRis the gold standard for the diagnosis of many infectious diseasesbut generally only implemented in well equipped laboratoriesOne of the major roadblocks for expanding PCR to point of care markets is the lack of simplerobustsingle tube PCR designs which preserve its laboratory based high sensitivity and specificityIn this Fast Track STTR a ...

Expressing humanized bacterial luciferase in stem cellsMoving beyond firefly luciferase toexpand the informational capacity of animal models for regenerative medicine Project Summary This Small Business Technology TransferSTTRPhase II project proposes to develop complementary autonomously bioluminescentautobioluminescentin vitro stem cell lines and in vivo small animal model systems that enable th ...

SpringActive Inc. collaborating with Arizona State University will design and build a spring-based, passive prosthetic ankle that stores energy in the stance phase and returns it at push-off to propel the user forward. The team will leverage experience in designing tuned spring ankles. A plantarflexion spring will allow the ankle to plantarflex smoothly and align to the ground after heel strike. ...

This proposal aims to develop a wireless IMU (WIMU) activity recognition system for SpringActive`s powered ankle prosthesis, Odyssey. Robust activity detection via WIMU will revolutionize the state-of-the-art in powered, lower limb prosthetics by integrating (i) bio-inspired intelligence with (ii) biomimetic mechanics into a highly-maneuverable, smart, ankle-foot prosthesis system. Odyssey is the ...

The purpose of this proposed research is to develop and commercialize a novel two color sodium guidestar laser operating simultaneously at 589 nm and 1141 nm. Our patented T-cavity design combined with VECSEL technology will be the basis for the guidestar development. The polychromatic laser guidestar (PLGS) system being proposed currently does not exist and would allow for the correction of atmos ...

The mechanical testing of energetic materials makes experimentation highly expensive and hazardous. Therefore, an accurate and practical modeling approach is necessary to predict their mechanical properties. Numerous atomistic to continuum models exist to predict the properties of energetic materials. However, these methods are not coupled with each other in a systematic and practical way; thus, ...