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Because of its high sensitivity polymerase chain reaction PCR is the gold standard for the diagnosis of many infectious diseases but generally only implemented in well equipped laboratories One of the major roadblocks for expanding PCR to point of care markets is the lack of simple robust single tube PCR designs which preserve its laboratory based high sensitivity and specificity In this F ...

Abstract Primary central nervous system lymphoma PCNSL is an aggressive brain tumor with a dire unmet therapeutic need It has an overall incidence of per person years and is regarded as an orphan disease with potential for fast track approval Our group made a discovery via gene expression analysis that osteopontin OPN is the most upregulated gene in PCNSL compared to its non CNS ...

Summary Approximatelymillion women in the United States are at high risk for developing breast cancerbased on inheritance of a germline mutation in a gene in the double strand breakDSBrepair and cyclin checkpoint pathwaysMany are unaware of their genetic predispositionsbecause their family history is uninformative or unknownGenetic testing is important for identifying mutations in these genesbut i ...

Viruses from the human herpesvirus family are estimated to infectof the adult population worldwide and are responsible for lifelong debilitating and congenital infectionsSome members of this family are associated with human cancers and age related cognitive declineHerpes simplex virusHSVhas infected more thanbillion people under the age ofof the populationHSVcauses significant disease during acute ...

Because of its high sensitivitypolymerase chain reactionPCRis the gold standard for the diagnosis of many infectious diseasesbut generally only implemented in well equipped laboratoriesOne of the major roadblocks for expanding PCR to point of care markets is the lack of simplerobustsingle tube PCR designs which preserve its laboratory based high sensitivity and specificityIn this Fast Track STTR a ...

Expressing humanized bacterial luciferase in stem cellsMoving beyond firefly luciferase toexpand the informational capacity of animal models for regenerative medicine Project Summary This Small Business Technology TransferSTTRPhase II project proposes to develop complementary autonomously bioluminescentautobioluminescentin vitro stem cell lines and in vivo small animal model systems that enable th ...

Structural degradation and failure can cause malfunctions and long-term problems aboard spacecraft, jeopardizing the crew, especially in deep space missions. On Off-world habitats, this can lead to extensive maintenance procedures and dangerous EVAs to fix malfunctions. Micrometeorite impact and shielding breaches can have lasting impacts that pose a significant hazard to the longevity of mission ...

GTL has developed an innovative composite repair methodology known as the Composite Repair System (CRS). In this phase I effort, CRS is being developed for the repair of damaged induced in thin-laminate composite cryotanks. In applying CRS to damaged composite structures, the required level of structural capacity is recovered to within a predetermined percentage of its original performance after ...

In the Phase I effort, Gloyer-Taylor Laboratories LLC (GTL) verified the feasibility of generating power from space particle radiation. This effort successfully demonstrated electrical power production from a particle radiation source using an initial proof-of-concept device. The effort also identified a second approach that has the potential for even better power generation and offers enhanced ...

This Small Business Technology Transfer Research Phase II will develop and advance the commercialization of STF-ArmorTM nanocomposite materials for use in Environmental Protection Garments (EPG) for extended exploration missions in diverse environments, including LEO, cis-lunar space, and Lunar and Martian surfaces. The Phase II research will optimize and deliver a validated prototype suit compon ...