Award Data

ABSTRACT The primary objective of surgical therapy for the treatment of patients with any cancer is to remove all cancer cells from within the bodywith the secondary objective of maintaining organ functionThe primary pathological metric used to rate the success of a surgical procedure is evaluation of the surgical margin of the resected tissue specimenpost operativelyThis typically involves cuttin ...

Executive Summary of Predicate (One Page) Summary of Specific Aims of Phase I Specific Aim 1: Train and evaluate an algorithm to detect pediatric asthma symptoms (cough and wheeze) on a low power, small form factor wearable device. Specifications: 90% sensitivity; false alarm rate: 1 cough episode/day or 1 wheeze episode/day. Evaluate algorithm against medical expert (physician) scoring using the ...

Project Summary Abstract Millions of people in the US misuse opioids each yearleading to thousands of deaths and costing billions of dollars in total economic burdenMedication assisted treatmentMATfor opioid use disorderOUDis highly efficaciousbut only a fraction of OUD persons access MATand treatment non adherence is common and associated with poor outcomesThis STTR Fast Track proposal is designe ...

Project Summary AbstractThe objective of this proposal is to perform proof of concept experiments for a new thin walledsteerable sheath that can pass through a standard colonoscope port and dexterously maneuver surgical instruments at its tipClinical significance comes from the fact that overpatients per year in the USA have unnecessaryinvasive surgery to remove a section of their colonClinical li ...

Our overarching goal is to develop a monoclonal antibody based product for the prevention of seasonal influenza in high risk patientsIt is estimated there aredeaths annually related to seasonal influenza worldwideIn the United Statestheinfluenza season was classified a high severity season withdeathsandhospitalizations attributed to influenzaserving as a reminder of the continued severity of influ ...

PROJECT SUMMARYAn estimatedbillion antibiotic prescriptions were filled in the US fromDespite a national antibiotic education campaignapproximatelyof antibiotic prescriptions are unnecessaryAs a result of the over prescription of antibioticsthere is a current and pressing public health need for improved antibiotic stewardshipCompounding this problem are new modalities of healthcare like telemedici ...

PROJECT SUMMARY ABSTRACTUltrasound isand is poised to remaina ubiquitous biomedical imaging modalityIt is safefasteffectiveand affordableUltrasound imaging innovations are being actively developed to provide inexpensive solutions to public health concerns in areas as diverse as early cancer detectiontargeted drug deliveryand image guided surgeryYet significant barriers to research and innovation i ...

PROJECT SUMMARY ABSTRACT Clinical NeedThe coming decades promise a revolution in the therapies available for patients with generalized neuromuscular diseasesGNMDsincluding muscular dystrophyamyotrophic lateral sclerosisspinal muscular atrophymyasthenia gravisand a variety of acquired myopathiesHoweverin order to help facilitate thisthe academic and industrial clinical research communities need imp ...

Project Abstract The opioid epidemic is the U S andapos s most widespread behavioral public health problemwith a higher number of deaths due to drug overdose incompared to deaths due to HIV at the peak of the AIDS epidemicMedication assisted treatmentMATfor opioid use disorderOUDis highly efficaciousHoweveronly a fraction of persons with OUD access MATand treatment non adherence and drop out is co ...

Project Summary / Abstract: COVID-19, the clinical presentation associated with SARS-CoV-2 infection, has already profoundly impacted healthcare systems globally. Of particular note, communities such as long-term care facilities, assisted living communities, and prisons, are being devastated because of their high density of vulnerable individuals. Nursing home residents, which represent only 0.5% ...