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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Enabling point of care molecular diagnostics by developing an adaptive PCR instrument and on demand kit reagents

    SBC: BIOVENTURES, INC            Topic: 172

    Because of its high sensitivity polymerase chain reaction PCR is the gold standard for the diagnosis of many infectious diseases but generally only implemented in well equipped laboratories One of the major roadblocks for expanding PCR to point of care markets is the lack of simple robust single tube PCR designs which preserve its laboratory based high sensitivity and specificity In this F ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. A novel product for tendinopathy treatment


    Project Summary This study aims to prove the concept and feasibility that TendonCure extracellular vesicles that contain signaling molecules i e exosomes secreted by mesenchymal stem cells i e tendon stem progenitor cells TSPCs or adipose derived stem cells ADSCs from individual patients donors cultured on a novel scaffold exert therapeutic efficacy on tendinopathy when injected into ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Microfabrication based Biomimetic Approach for In Vitro Red Blood Cell Maturation

    SBC: Simpore Inc.            Topic: NHLBI

    Abstract The overall goal of this proposal is to develop systems for efficient ex vivo maturation of functional human red blood cells RBCs which holds tremendous potential for addressing supply bottlenecks for delivering new therapeutic options to chronically transfused patients with severe alloimmunization and for novel strategies for delivering therapeutics via engineered RBCs No approaches ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Structure based optimization of a novel pharmacological chaperone therapy for MPSIIIC

    SBC: Phoenix Nest Inc.            Topic: NICHD

    PROJECT SUMMARY Lysosomal storage diseases LSD are rare inherited metabolic disorders caused by defects in the cellular catabolic system Mucopolysaccharidosis Type IIIC MPS IIIC or Sanfilippo disease type C is one such LSD that is caused by deficiency of the enzyme heparan sulfate acetyl CoA glucosaminide N acetyltransferase HGSNAT essential for degradation of heparan sulfate a repeati ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Innovative Tools for Three Dimensional Traction Force Microscopy of Single Cells

    SBC: SIMMETRIX INC.            Topic: 102

    Project Summary Tractions exerted by individual cells on their surroundings play a critical role in mechanical events in biology such as tissue contraction folding cell shape changes or cell movements and in many basic cellular functions such as biochemical signaling proliferation and differentiation These processes are in turn implicated in the progression of diseases like cancer atherosc ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. In Situ Summarization for Existing Petascale and Future Exascale HPC Infrastructures

    SBC: Kitware, Inc.            Topic: A17AT010

    We propose extending our existing, scalable in situ visualization and analysis infrastructure -- based on VTK, VTK-m, and SENSEI -- to include summarization and compression algorithms. In Phase I, we will investigate summarization and compression algorithms, comparing wavelet-based techniques cited in the call to statistics-on-features, sorting-based compression, and feature-based extracts that pr ...

    STTR Phase I 2017 Department of DefenseArmy
  7. Freeze Casting of Tubular Sulfur Tolerant Materials for Solid Oxide Fuel Cells

    SBC: Millennitek, LLC            Topic: A14AT011

    Solid oxide fuel cells have long suffered from degradation due to impurities in the fuel and complexities associated with dissimilar materials and high operating temperatures.This degradation lowers the usable cell power output and requires ancillary equipment for fuel sulfur removal and reformation.A unique microstructure for the tubular anode will be produced using a novel freeze-casting techniq ...

    STTR Phase II 2017 Department of DefenseArmy
  8. Energy Efficient, Non-Silicon Digital Signal Processing (DSP)

    SBC: HYPRES, INC.            Topic: N17AT027

    Superconductor digital circuits, operating at very high clock speed, can directly process wideband digitized radio frequency (RF) signals. By integrating such digital processing circuitry together with superconductor analog-to-digital converters (ADCs), we propose to develop the next generation digital-RF receivers. Leveraging the recent development of multiple superconductor ADCs on the same chip ...

    STTR Phase I 2017 Department of DefenseNavy
  9. Ultra scaling of SPAD arrays for high-speed laser ranging

    SBC: Lightspin Technologies Inc            Topic: N15AT011

    Ultrasensitive detection of visible light has a wide range of applications, including laser ranging and free space optical communications. Ultimate sensitivity is achieved when individual return photons are counted with high probabilities of detection, low probabilities of false detection, and precision timing. Previously, high bandwidth was only achieved with PIN photodiode and avalanche photodio ...

    STTR Phase II 2017 Department of DefenseNavy
  10. Thermal Barrier Coatings for Long Life in Marine Gas Turbine Engines

    SBC: RELIACOAT TECHNOLOGIES, LLC            Topic: N16AT019

    Due to high power density and durability, gas turbines provide significant benefits in terms of efficiency and performance that in recent years, marine gas turbines have been deployed in commercial and cruise ships. Marine gas turbine technologies are essentially extensions of aero-gas turbine technology. Aero, land and marine engines have been used successfully for decades, recently there have be ...

    STTR Phase II 2017 Department of DefenseNavy

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