Award Data

Because of its high sensitivity polymerase chain reaction PCR is the gold standard for the diagnosis of many infectious diseases but generally only implemented in well equipped laboratories One of the major roadblocks for expanding PCR to point of care markets is the lack of simple robust single tube PCR designs which preserve its laboratory based high sensitivity and specificity In this F ...

PROJECT SUMMARY ABSTRACT Over a quarter of primary care patients in the United States can be classified as unhealthy drinkers because their alcohol use conveys a high risk of health and social consequences Unfortunately unhealthy drinking is under recognized in spite of the existence of valid screening tools Even when unhealthy drinking is recognized barriers such as provider discomfort shor ...

ABSTRACT SUMMARY The outcome of this phase project will yield a turnkey system for spectroscopy polarimetry in the terahertz THz frequency range designed to support development of new drugs This system will directly probe protein vibrations using polarized terahertz radiation allowing researchers to rapidly characterize intramolecular vibrations which will help identify sites on ...

PROJECT SUMMARY ABSTRACT Our recently completed Phaseanimal studies demonstrated the ability of our novel second generation partialp MHC constructDRhMOGto treat acute and chronic EAE with potency comparable to the parent RTLmoleculepDRMOGin matched DRTg mice and in DRnegative mismatched miceHaving met our Phasemilestonesour Phase II application will produce a fully humanized DRhMOGmolecule and ass ...

This is a Phase I STTR to investigate the preclinical efficacy of a novel immunomodulator DR MOG in a clinically relevant thromboembolic stroke model in mice We have previously shown that T cells are activated after stroke infiltrate brain and exacerbate ischemic brain damage Strategies that reduce T cell activation and brain tissue infiltration have been investigated as potential therapeu ...

Because of its high sensitivitypolymerase chain reactionPCRis the gold standard for the diagnosis of many infectious diseasesbut generally only implemented in well equipped laboratoriesOne of the major roadblocks for expanding PCR to point of care markets is the lack of simplerobustsingle tube PCR designs which preserve its laboratory based high sensitivity and specificityIn this Fast Track STTR a ...

Expressing humanized bacterial luciferase in stem cellsMoving beyond firefly luciferase toexpand the informational capacity of animal models for regenerative medicine Project Summary This Small Business Technology TransferSTTRPhase II project proposes to develop complementary autonomously bioluminescentautobioluminescentin vitro stem cell lines and in vivo small animal model systems that enable th ...

The U.S. Air Force trains and educates a large and diverse workforce to meet requirements across a complex array of missions. Early-stage training in many Air Force Specialty Codes can consist of large corpora of foundational, static material, so training that motivates airmen is a necessary element in helping ensure a supply of qualified personnel in mission-critical areas like aerospace maintena ...

Optical limiters (OL) protect sensitive optical and electronic devices from laser-induced damage. The existing passive OL utilize nonlinear optical materials transmitting low-intensity light, while blocking laser radiation with intensity exceeding certain limiting threshold (LT). The common problem with the existing OL is that, at any particular frequency range, the choice of suitable nonlinear ...

The Air Force has identified a need for a display agnostic common streaming model for 3D data. Third Dimension Technologies (TDT) and Oak Ridge National Laboratory (ORNL) have formed a consortium to define a 3D streaming model based on open standards for Display Agnostic 3D Streaming (DA3DS). Two factors are driving this need. The first is the dramatic increase in the collection, storage and trans ...