Award Data

DESCRIPTIONprovided by applicantThe Cell SafeTM is a fundamentally new approach in replacement of dysfunctional insulin producing cells in patients with diabetesby transplantation of new islets in a three dimensional scaffold embedded in a highly compatible bioengineered perfusion system that continuously supplies tissue fluidblood ultrafiltrateso that the cells ae protected from immune rejection ...

DESCRIPTIONprovided by applicantCardiovascular diseases and Asthma affects betweenandmillion people in the United States includingmillion childrenduring the pastyearsits incidence worldwide has doubledAsthma is responsible formillion person days of restricted activity anddeaths per yearamounting to $billion in direct heath related coststhere is uncertainty about the specific factors that are contr ...

There is a fundamental knowledge gap in how to immediately reduce cancer patientstreatment related financial burdenCancer patients pay more out of pocket for their care than those with other chronic illnessesHalf of all elderly cancer patients have high treatment related out of pocket financial burdenThis financial burden has well defined harmful effects even among insured cancer patients includin ...

Because of its high sensitivity polymerase chain reaction PCR is the gold standard for the diagnosis of many infectious diseases but generally only implemented in well equipped laboratories One of the major roadblocks for expanding PCR to point of care markets is the lack of simple robust single tube PCR designs which preserve its laboratory based high sensitivity and specificity In this F ...

Project Summary Chagas disease is a severe inflammatory syndrome caused by infection with a protozoan parasite Trypanosoma cruzi Although transmission occurs mostly through an intermediate insect host the infection is silent and chronic carriers pose a significant risk through the transfer of infected products made from donated blood of these individuals to blood recipients Up to new c ...

ABSTRACT Alzheimerandapos s and other tauopathies are medical problems growing to historical proportions that threaten the long term viability of medical care systems world wide Alzheimerandapos s costs today are of the US GDP and growing as the population ages Effective disease modifying treatments have yet to be developed A number of drugs in clinical testing target amyloid but very fe ...

Project Abstract Short interpregnancy intervals IPIs pose risks for mothers and newborns alike including preterm birth low birth weight small for gestational age and placental abruption IPIs of less than months increase risk of neonatal death Short IPIs are a source of major health disparities and disproportionately affect African American adolescents Postpartum contraception signific ...

Given the rapidly aging population and the incidence of age related eye diseases the number of individuals with low vision is expected to increase dramatically in the next decades Patients with central vision loss can no longer use their foveas and eccentric retina must be used to perform visual tasks Since the peripheral retina has reduced sensory capabilities and altered oculomotor behavior ...

Project Abstract The proposed Phase I STTR project will develop the serious game Prognosis and its supporting website to improve systems thinking and problem solving through learning about public health and epidemiology Prognosis is a simulation game that focuses on the population health of the fictional city Hexacago Through game play players will learn how multiple ambient citywide systems ...

We aim to develop a transcranial Doppler TCD ultrasound simulator on a physical mannequin for realistic medical training and professional competence testing The Specific Aims of the project are Develop a prototype TCD simulator The anatomy of the cerebrovascular system CVS will be reconstructed in three dimensional D from a patient s computed tomography angiogram CTA The blood flow ...