Award Data

Because of its high sensitivity polymerase chain reaction PCR is the gold standard for the diagnosis of many infectious diseases but generally only implemented in well equipped laboratories One of the major roadblocks for expanding PCR to point of care markets is the lack of simple robust single tube PCR designs which preserve its laboratory based high sensitivity and specificity In this F ...

Project Summary Abstract Mitochondrial dysfunction causes mitochondrial diseases and is tightly linked to aging and neurodegenerative disorders such as Parkinsonandapos s and Alzheimerandapos s Recent discoveries support that mitochondrial dysfunction can be overcome to treat age related decline Cytegenandapos s hypothesis is that exercise induces the secretion of blood borne proteins that act ...

Plasmodium falciparum is the most virulent form of malaria causing million deaths per year Success with patient treatment and a malaria eradication campaign depends significantly on our ability to detect new infections as early as possible in the field rural areas including asymptomatic cases preferably using a small amount of blood e g from a finger prick and to clearly discrim ...

Project Summary Stem cell research has shown great potential to help treat or even cure a wide array of health conditions including cardiovascular and neurological disease cancer and diabetes This field is now beginning to move rapidly from the re search stage to clinical translation and commercial applications However it has been widely recognized that stem cell scientists have difficulty ...

PROJECT SUMMARY There is an increasing public concern about monitoring water quality in the entire drinking water supply system especially at the point of use spurred by recent water catastrophes such as the one in Flint Michigan that has caused severe health issues for thousands of children due to the unsafe level of lead in contaminated drinking water Current quantitative detection methods ...

Because of its high sensitivitypolymerase chain reactionPCRis the gold standard for the diagnosis of many infectious diseasesbut generally only implemented in well equipped laboratoriesOne of the major roadblocks for expanding PCR to point of care markets is the lack of simplerobustsingle tube PCR designs which preserve its laboratory based high sensitivity and specificityIn this Fast Track STTR a ...

Biological tissues collection is problematic and risky even under ideal conditions: when collection occurs in remote locations, or by minimally-trained personnel, as may occur in response to an emerging disease threat, risks are magnified. This proposal addresses this issue by developing a Field Fixation Unit (FFU) for specimen collection that utilizes single-use capsules pre-loaded with fixative. ...

Platypus will leverage its scientific gains in the advancement of liquid crystal-based (LC) sensors to develop light weight, accurate, and instantaneous multi-target LC gas sensor systems with telemetry and low power consumption for retrofit or OEM integration onto unmanned vehicles (UMVs). We will also develop a computational design guide for the rapid production and deployment of LC sensors for ...

Solid oxide fuel cells have long suffered from degradation due to impurities in the fuel and complexities associated with dissimilar materials and high operating temperatures.This degradation lowers the usable cell power output and requires ancillary equipment for fuel sulfur removal and reformation.A unique microstructure for the tubular anode will be produced using a novel freeze-casting techniq ...

The technical objectives of this proposal are: 1) perform a comprehensive simulation of 4.6 micron-emitting quantum cascade lasers (QCLs) with suppressed carrier leakage and efficient carrier extraction to design a device with pulsed wall-plug efficiency > 40 %; 2) perform a thermal analysis of 4.6 micron-emitting QCLs to design structures capable of operating with > 40 % continuous-wave (CW) wall ...